Oncotarget

Meta-Analysis:

Association of three promoter polymorphisms in interleukin-10 gene with cancer susceptibility in the Chinese population: a meta-analysis

Ping Wang, Junling An, Yanfeng Zhu, Xuedong Wan, Hongzhen Zhang, Shoumin Xi _ and Sanqiang Li

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Oncotarget. 2017; 8:62382-62399. https://doi.org/10.18632/oncotarget.18220

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Abstract

Ping Wang1, Junling An1, Yanfeng Zhu1, Xuedong Wan1, Hongzhen Zhang1, Shoumin Xi1 and Sanqiang Li2

1The Key Laboratory of Pharmacology and Medical Molecular Biology, Medical College, Henan University of Science and Technology, Luoyang 471023, Henan, China

2The Molecular Medicine Key Laboratory of Liver Injury and Repair, Medical College, Henan University of Science and Technology, Luoyang 471023, Henan, China

Correspondence to:

Shoumin Xi, email: xishoumin@haust.edu.cn

Sanqiang Li, email: lsqhkd@163.com

Keywords: interleukin-10, polymorphism, cancer, susceptibility, meta-analysis

Received: March 15, 2017     Accepted: April 14, 2017     Published: May 26, 2017

ABSTRACT

Numerous studies have examined the associations of three promoter polymorphisms (-1082A/G, -819T/C and -592A/C) in IL-10 gene with cancer susceptibility in the Chinese population, but the results remain inconclusive. To gain a more precise estimation of this potential association, we conducted the current meta-analysis based on 53 articles, including 26 studies with 4,901 cases and 6,426 controls for the -1082A/G polymorphism, 33 studies with 6,717 cases and 8,550 controls for the -819T/C polymorphism, and 42 studies with 9,934 cases and 13,169 controls for the -592A/C polymorphism. Pooled results indicated that the three promoter polymorphisms in IL-10 gene were significantly associated with an increased overall cancer risk in the Chinese population. Stratification analysis showed that the association was more pronounced for hepatocellular carcinoma and low quality studies for the -1082A/G polymorphism, lung cancer and oral cancer for the -819T/C polymorphism. However, the -592A/C polymorphism was associated with a statistically significant increased risk for lung cancer, oral cancer, hospital-based studies and low quality studies, but a decreased risk for colorectal cancer. We further investigated the significant results using the false-positive report probability (FPRP) test. Interestingly, FPRP test results revealed that only IL-10 -1082A/G polymorphism was truly associated with an increased overall cancer risk. In the subgroup analysis, only the low quality studies, lung cancer and colorectal cancer remained significant at the prior level of 0.1. Although this association needs further confirmation by considering large studies, this meta-analysis suggested an association between IL-10 gene polymorphisms and cancer risk in the Chinese population.


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