Oncotarget

Research Papers:

Serum cystatin C is associated with large cerebral artery stenosis in acute ischemic stroke

Zhiqiang Xu, Cuihua Leng, Bo Yang, Haili Wang, Jing Sun, Zhaoxia Liu, Lingli Yang, Wei Ge and Jiangtao Zhu _

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Oncotarget. 2017; 8:67181-67188. https://doi.org/10.18632/oncotarget.18061

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Abstract

Zhiqiang Xu1,*, Cuihua Leng1,*, Bo Yang1,*, Haili Wang2, Jing Sun1, Zhaoxia Liu1, Lingli Yang1, Wei Ge2 and Jiangtao Zhu3

1Department of Neurology, The Second Affiliated Hospital of Soochow University, Suzhou City, Jiangsu, China

2Department of Neurology, The Affiliated Hospital of Xuzhou Medical University, Xuzhou City, Jiangsu, China

3Department of Radiology, The Second Affiliated Hospital of Soochow University, Suzhou City, Jiangsu, China

*These authors have contributed equally to this work

Correspondence to:

Jiangtao Zhu, email: jiangtaozhu@126.com

Wei Ge, email: gw1003@163.com

Keywords: acute ischemic stroke, large cerebral artery stenosis, cystatin C, risk factors

Received: March 10, 2017    Accepted: April 19, 2017    Published: May 22, 2017

ABSTRACT

Large cerebral artery stenosis is a major cause of acute ischemic stroke (AIS); however, the correlation between serum cystatin C (CysC) and the stenosis of large cerebral arteries in patients with AIS has not been established. We performed a retrospective review of acute ischemic stroke patients, who were examined by cerebral digital subtraction angiography(DSA). Participants (252 cases) included 131 patients without stenosis and 121 patients with large cerebral artery stenosis. Serum CysC levels in patients with large cerebral artery stenosis were much higher than that of control subjects (p<0.001). However, serum CysC levels were not related to the location of stenosis. Further, logistic regression analyses showed that increased serum CysC was an independent risk factor of large cerebral artery stenosis in patients with acute ischemic stroke. Total participants were subdivided into quintiles based on serum CysC levels. Compared with the first quintile, the odds ratios of risk for large cerebral artery stenosis in the fourth and the fifth quintile were 1.26 (p<0.05) and 4.71(p<0.05) respectively, after the adjustment for age, sex, and smoking, hypertension, type 2 diabetes mellitus(DM), dyslipidemia, creatinine(Cr), urea, uric acid, and C reactive protein(CRP). Therefore, a significant positive correlation was observed between elevated serum CysC levels and large cerebral artery stenosis in patients with acute ischemic stroke. In summary, our findings provide new insights into the correlation between increased serum CysC and large cerebral artery stenosis in patients with acute ischemic stroke.


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