From rapalogs to anti-aging formula
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Mikhail V. Blagosklonny
1 Cell Stress Biology, Roswell Park Cancer Institute, Buffalo, NY, USA
Mikhail V. Blagosklonny, email:
Keywords: lifespan, longevity, rejuvenation, health, diseases
Received: February 17, 2017 Accepted: April 30, 2017 Published: May 22, 2017
Inhibitors of mTOR, including clinically available rapalogs such as rapamycin (Sirolimus) and Everolimus, are gerosuppressants, which suppress cellular senescence. Rapamycin slows aging and extends life span in a variety of species from worm to mammals. Rapalogs can prevent age-related diseases, including cancer, atherosclerosis, obesity, neurodegeneration and retinopathy and potentially rejuvenate stem cells, immunity and metabolism. Here, I further suggest how rapamycin can be combined with metformin, inhibitors of angiotensin II signaling (Losartan, Lisinopril), statins (simvastatin, atorvastatin), propranolol, aspirin and a PDE5 inhibitor. Rational combinations of these drugs with physical exercise and an anti-aging diet (Koschei formula) can maximize their anti-aging effects and decrease side effects.
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