Research Papers:
Relationship between expression of PD-L1 and tumor angiogenesis, proliferation, and invasion in glioma
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Abstract
Song Xue1,2,3,*, Man Hu2,3,4,*, Peifeng Li5, Ji Ma4,6, Li Xie4,7, Feifei Teng2,3,4, Yufang Zhu4,8, Bingjie Fan2,3,4, Dianbin Mu4,9 and Jinming Yu2,3,4
1School of Medicine and Life Sciences, University of Jinan-Shandong Academy of Medical Sciences, Jinan, Shandong, China
2Shandong Academy of Medical Sciences, Jinan, Shandong, China
3Department of Radiation Oncology, Shandong Province Key Laboratory of Radiation Oncology, Shandong Cancer Hospital and Institute, Jinan, Shandong, China
4Shandong Cancer Hospital Affiliated to Shandong University, Jinan, Shandong, China
5Department of Pathology, General Hospital of Jinan Military Command, Jinan, Shandong, China
6Department of Medicine, Shandong Cancer Hospital and Institute, Jinan, Shandong, China
7Shandong Provincial Key Laboratory of Radiation Oncology, Shandong Cancer Hospital and Institute, Jinan, Shandong, China
8Department of Neurosurgery, Shandong Cancer Hospital and Institute, Jinan, Shandong, China
9Department of Pathology, Shandong Cancer Hospital and Institute, Jinan, Shandong, China
*These authors contributed equally to this work
Correspondence to:
Dianbin Mu, email: [email protected]
Jinming Yu, email: [email protected]
Keywords: PD-L1, angiogenesis, proliferation, invasion, glioma
Received: January 26, 2017 Accepted: May 01, 2017 Published: May 17, 2017
ABSTRACT
Programmed death ligand 1 (PD-L1) is highly expressed in many cancers. We investigated the expression of PD-L1 and its relationship with vascular endothelial growth factor (VEGF), matrix metalloproteinase-9 and KI-67 expression in 64 patients with primary glioma. The expression rate of PD-L1 in glioma patients was 78.12%. PD-L1 levels correlated with the tumor grade (p = 0.013), VEGF status (p = 0.002) and KI-67 status (p = 0.002). In addition, PD-L1 levels correlated positively with VEGF (r = 0.314, p = 0.011) and KI-67 (r = 0.391, p = 0.001) levels when the data were treated as continuous variables. This is the first report suggesting that PD-L1 is important for glioma angiogenesis and proliferation. Thus, further research should be conducted to assess the combination of targeted VEGF therapy and anti-PD-L1 immunotherapy for the treatment of glioma.
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