Microbiota-gut-brain axis and the central nervous system

Xiqun Zhu; Yong Han; Jing Du; Renzhong Liu; Ketao Jin; Wei Yi

doi:10.18632/oncotarget.17754

Oncotarget

Oncotarget (a primarily oncology-focused, peer-reviewed, open access journal) aims to maximize research impact through insightful peer-review; eliminate borders between specialties by linking different fields of oncology, cancer research and biomedical sciences; and foster application of basic and clinical science.

Its scope is unique. The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. The term was introduced in the inaugural Editorial, Introducing Oncotarget.

As of January 1, 2022, Oncotarget has shifted to a continuous publishing model. Papers will now be published continuously within yearly volumes in their final and complete form and then quickly released to Pubmed.

Subscribe to receive alerts once a paper has been published by Oncotarget.

Impact Journals, LLC is the publisher of Oncotarget: www.impactjournals.com.

Impact Journals is a member of the Wellcome Trust List of Compliant Publishers.

Impact Journals is a member of the Society for Scholarly Publishing.

On December 23, 2022, Oncotarget server experienced a DDoS attack. As a result, Oncotarget site was inaccessible for a few hours. Oncotarget team swiftly dealt with the situation and took it under control. This malicious action will be reported to the FBI.

Reviews:

Microbiota-gut-brain axis and the central nervous system

Xiqun Zhu, Yong Han, Jing Du, Renzhong Liu, Ketao Jin and Wei Yi _

PDF | HTML | How to cite

Oncotarget. 2017; 8:53829-53838. https://doi.org/10.18632/oncotarget.17754

Metrics: PDF 7412 views | HTML 12069 views | ?

Abstract

Xiqun Zhu1,*, Yong Han2,*, Jing Du3,*, Renzhong Liu1, Ketao Jin4 and Wei Yi1

1Department of Neurosurgery, Renmin Hospital of Wuhan University, Wuhan, Hubei, P.R. China

2Clinical Research Institute, Zhejiang Provincial People’s Hospital, Hangzhou, Zhejiang, P.R. China

3Department of Gastroenterology, Zhejiang Provincial People’s Hospital, Hangzhou, Zhejiang, P.R. China

4Department of Gastrointestinal Surgery, Shaoxing People’s Hospital, Shaoxing Hospital of Zhejiang University, Shaoxing, Zhejiang, P.R. China

*These authors contributed equally to this work

Correspondence to:

Wei Yi, email: [email protected]

Ketao Jin, email: [email protected]

Keywords: gut microorganism, microbiota-gut-brain axis, central nervous system, disorders

Received: April 19, 2017 Accepted: April 26, 2017 Published: May 10, 2017

ABSTRACT

The gut and brain form the gut-brain axis through bidirectional nervous, endocrine, and immune communications. Changes in one of the organs will affect the other organs. Disorders in the composition and quantity of gut microorganisms can affect both the enteric nervous system and the central nervous system (CNS), thereby indicating the existence of a microbiota-gut-brain axis. Due to the intricate interactions between the gut and the brain, gut symbiotic microorganisms are closely associated with various CNS diseases, such as Parkinson's disease, Alzheimer's disease, schizophrenia, and multiple sclerosis. In this paper, we will review the latest advances of studies on the correlation between gut microorganisms and CNS functions & diseases.

All site content, except where otherwise noted, is licensed under a Creative Commons Attribution 4.0 License.
PII: 17754

Publication Alerts

Reviews:

Microbiota-gut-brain axis and the central nervous system

Abstract