Oncotarget

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A summary of relationships between alternative splicing and breast cancer

Zhang Xiping _, Wei Qingshan, Zhao Shuai, Yang Hongjian and Ding Xiaowen

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Oncotarget. 2017; 8:51986-51993. https://doi.org/10.18632/oncotarget.17727

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Abstract

Zhang Xiping1, Wei Qingshan2, Zhao Shuai1, Yang Hongjian1 and Ding Xiaowen1

1Department of Breast Surgery, Zhejiang Cancer Hospital, Hangzhou 310022, Zhejiang Province, China

2Cataloging Department, Library of Xi‛an Jiaotong University, Xi'an 710049, Shaanxi Province, China

Correspondence to:

Zhang Xiping, email: 626876448@qq.com

Keywords: alternative splicing, breast cancer, spliceosome, variants

Received: January 17, 2017     Accepted: April 05, 2017     Published: May 09, 2017

ABSTRACT

Alternative splicing (AS) is the process of combinatorial rearrangement of parts of exons, and/or parts of introns into mature RNA to result in a multitude of transcripts. AS is a biological process through which organisms produce as many protein variants as possible by a limited genetic resource. It plays an important role in growth and development of the organisms. Over the past few years, alternative splicing has been discovered to be critical for genesis and development of malignant tumors, including breast cancer. If the relationships between AS and breast cancer can be discussed more deeply, it will be helpful for better diagnosis, judging prognosis and intervening with breast cancer. In this paper, the relationships between AS and breast cancer are elaborated from different angles, in hope that this summary is beneficial for readers to understand the roles of AS and breast cancer.


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