A summary of relationships between alternative splicing and breast cancer
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Zhang Xiping1, Wei Qingshan2, Zhao Shuai1, Yang Hongjian1 and Ding Xiaowen1
1Department of Breast Surgery, Zhejiang Cancer Hospital, Hangzhou 310022, Zhejiang Province, China
2Cataloging Department, Library of Xi‛an Jiaotong University, Xi'an 710049, Shaanxi Province, China
Zhang Xiping, email: email@example.com
Keywords: alternative splicing, breast cancer, spliceosome, variants
Received: January 17, 2017 Accepted: April 05, 2017 Published: May 09, 2017
Alternative splicing (AS) is the process of combinatorial rearrangement of parts of exons, and/or parts of introns into mature RNA to result in a multitude of transcripts. AS is a biological process through which organisms produce as many protein variants as possible by a limited genetic resource. It plays an important role in growth and development of the organisms. Over the past few years, alternative splicing has been discovered to be critical for genesis and development of malignant tumors, including breast cancer. If the relationships between AS and breast cancer can be discussed more deeply, it will be helpful for better diagnosis, judging prognosis and intervening with breast cancer. In this paper, the relationships between AS and breast cancer are elaborated from different angles, in hope that this summary is beneficial for readers to understand the roles of AS and breast cancer.
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