Oncotarget

Research Papers:

Characterization of Sudan Ebolavirus infection in ferrets

Andrea Kroeker, Shihua He, Marc-Antoine de La Vega, Gary Wong, Carissa Embury-Hyatt and Xiangguo Qiu _

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Oncotarget. 2017; 8:46262-46272. https://doi.org/10.18632/oncotarget.17694

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Abstract

Andrea Kroeker1,2, Shihua He1,2, Marc-Antoine de La Vega1,3,4, Gary Wong1,5, Carissa Embury-Hyatt6 and Xiangguo Qiu1,2

1Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba, Canada

2Department of Medical Microbiology, University of Manitoba, Winnipeg, Manitoba, Canada

3Department of Immunology, University of Manitoba, Winnipeg, Manitoba, Canada

4Département de microbiologie-infectiologie et d’immunologie, Université Laval, Quebec City, Québec, Canada

5CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China

6Canadian Food Inspection Agency, National Centre for Foreign Animal Disease, Winnipeg, Manitoba, Canada

Correspondence to:

Xiangguo Qiu, email: xiangguo.qiu@phac-aspc.gc.ca

Keywords: ferrets, Sudan, Ebolavirus, animal model, characterization

Received: October 05, 2016    Accepted: March 30, 2017    Published: May 08, 2017

ABSTRACT

Sudan virus (SUDV) outbreaks in Africa are highly lethal; however, the development and testing of novel antivirals and vaccines for this virus has been limited by a lack of suitable animal models. Non-human primates (NHP) remain the gold standard for modeling filovirus disease, but they are not conducive to screening large numbers of experimental compounds and should only be used to test the most promising candidates. Therefore, other smaller animal models are a valuable asset. We have recently developed a guinea-pig adapted SUDV virus that is lethal in guinea pigs. In our current study, we show that ferrets are susceptible to wild-type SUDV, providing a small animal model to directly study clinical isolates, screen experimental anti-SUDV compounds and potentially study viral transmission.


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