Oncotarget

Research Papers:

Determination of IL-1B (rs16944) and IL-6 (rs1800796) genetic polymorphisms in IgA nephropathy in a northwest Chinese Han population

Daofa Zhang, Maowei Xie, Xiaohong Yang, Yin Zhang, Yan Su, Yanni Wang, Haiyang Huang, Hui Han, Wenning Li, Keying Fu, Huiluan Su, Wentan Xu, Yeguang Han, Ru Wang, Pei Zhang, Wei Wu, Yun Huang, Daojun Chen, Tianbo Jin and Jiali Wei _

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Oncotarget. 2017; 8:71750-71758. https://doi.org/10.18632/oncotarget.17603

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Abstract

Daofa Zhang1,*, Maowei Xie1,*, Xiaohong Yang1,*, Yin Zhang1, Yan Su1, Yanni Wang1, Haiyang Huang2, Hui Han1, Wenning Li1, Keying Fu2, Huiluan Su1, Wentan Xu1, Yeguang Han2, Ru Wang2, Pei Zhang2, Wei Wu1, Yun Huang1, Daojun Chen1, Tianbo Jin3,4 and Jiali Wei1

1Department of Nephrology, Hainan General Hospital, Haikou, Hainan 570311, China

2Central Laboratory, Hainan General Hospital, Haikou, Hainan 570311, China

3Key Laboratory of Resource Biology and Biotechnology in Western China, Northwest University, Ministry of Education, Xi’an, Shaanxi 710069, China

4Xi’an Tiangen Precision Medical Institute, Xi’an, Shaanxi 710075, China

*These authors have contributed equally to this work

Correspondence to:

Jiali Wei, email: wjl525@163.com

Keywords: IgAN, IL-1B, IL-6, Chinese Han population, genetics polymorphisms

Received: February 21, 2017    Accepted: April 15, 2017    Published: May 04, 2017

ABSTRACT

IgA nephropathy (IgAN) is the most common form of primary glomerulonephritis worldwide, but etiology and pathogenesis continue to be poorly understood. Polymorphisms in the cytokine genes may play a role in the etiology and pathogenesis of IgAN. The incidence of different between diverse ethnic groups suggested important genetic influences on its pathogenesis.

We genotype 10 single nucleotide polymorphisms (SNPs) in IL-1B and IL-6 gene using Sequenom Mass-ARRAY technology from 417 IgAN patients and 463 healthy controls of the Chinese Han population. We evaluated these SNPs associated with IgAN utilising the chi-square tests and genetic model analysis.

We identified that the minor alleles of rs16944 (“A”), rs1800796 (“G”) in IL-1B, IL-6 were involved in an increasingly risk of IgAN in allelic model analysis, respectively. The rs16944 in IL-1B and rs1800796 in IL-6 were associated with 1.23-fold (95% CI, 1.02-1.48, P = 0.031) and 1.33-fold (95% CI, 1.11-1.66, P = 0.003) increases in the risk of developing IgAN, respectively. There was only rs1800796 still correlated with IgAN in the allelic model after adjustment by age and gender and the Bonferroni correction. In addition, Haplotype Grs1800796A rs2069837G rs2069840 (P = 0.037) and G rs1800796A rs2069837C rs2069840 (P = 0.042) in IL-6were considered to be associated with increased IgAN risk.

This study verified the IL-6, IL-1B genetic variants polymorphisms contributed to IgAN susceptibility in a Chinese Han population. Although we identified SNPs susceptibility, however, replication studies and functional research are required to confirm the genetic contribution in IgAN.


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