Oncotarget

Research Papers:

Indirubin improves antioxidant and anti-inflammatory functions in lipopolysaccharide-challenged mice

Tianjie Qi, Haitao Li and Shuai Li _

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Oncotarget. 2017; 8:36658-36663. https://doi.org/10.18632/oncotarget.17560

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Abstract

Tianjie Qi1,*, Haitao Li1,*, Shuai Li1

1Department of Respiratory Medicine, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei 050000, P.R. China

*These authors contributed equally to this work and are co-first authors

Correspondence to:

Shuai Li, email: shuaili322@sina.com

Keywords: indirubin, acute lung injury, oxidative stress, inflammation, NF-κB

Received: March 22, 2017     Accepted: April 07, 2017     Published: May 02, 2017

ABSTRACT

Indirubin, a traditional Chinese medicine formulation from the Muricidae family, has been reported to exhibit abroad anti-cancer and anti-inflammation activities and mediate nuclear factor-κB (NF-κB) signal. Thus, this study aimed to investigate the protective effects of indirubin on LPS-induced acute lung injury and the potential mechanism in mice. The results showed that LPS treatment caused oxidative stress and inflammation in mice. Indirubin alleviated LPS-caused oxidative stress and inflammation via reducing MDA abundance and IL-1β and TNF-α expressions in mice. Meanwhile, indirubin improved lung NO production and inhibited NF-κB activation caused by LPS exposure. In conclusion, indirubin alleviated LPS-induced acute lung injury via improving antioxidant and anti-inflammatory functions, which might be associated with the NO and NF-κB signals.


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