Intercellular adhesion molecule 1 rs5498 polymorphism is associated with the risk of myocardial infarction

Pengfei Hu; Tao Dai; Weiwei Yu; Ying Luo; Shuwei Huang

doi:10.18632/oncotarget.17529

Oncotarget

Oncotarget (a primarily oncology-focused, peer-reviewed, open access journal) aims to maximize research impact through insightful peer-review; eliminate borders between specialties by linking different fields of oncology, cancer research and biomedical sciences; and foster application of basic and clinical science.

Its scope is unique. The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. The term was introduced in the inaugural Editorial, Introducing Oncotarget.

As of January 1, 2022, Oncotarget has shifted to a continuous publishing model. Papers will now be published continuously within yearly volumes in their final and complete form and then quickly released to Pubmed.

Subscribe to receive alerts once a paper has been published by Oncotarget.

Impact Journals, LLC is the publisher of Oncotarget: www.impactjournals.com.

Impact Journals is a member of the Wellcome Trust List of Compliant Publishers.

Impact Journals is a member of the Society for Scholarly Publishing.

On December 23, 2022, Oncotarget server experienced a DDoS attack. As a result, Oncotarget site was inaccessible for a few hours. Oncotarget team swiftly dealt with the situation and took it under control. This malicious action will be reported to the FBI.

Research Papers:

Intercellular adhesion molecule 1 rs5498 polymorphism is associated with the risk of myocardial infarction

Pengfei Hu, Tao Dai, Weiwei Yu, Ying Luo and Shuwei Huang _

PDF | HTML | How to cite

Oncotarget. 2017; 8:52594-52603. https://doi.org/10.18632/oncotarget.17529

Metrics: PDF 1306 views | HTML 1992 views | ?

Abstract

Pengfei Hu1,*, Tao Dai2,*, Weiwei Yu1, Ying Luo1 and Shuwei Huang1

1Department of Cardiology, The Second Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China

2Department of Cardiology, Yuhuangding Hospital Affiliated to Qingdao University, Yantai, Shandong, China

*These authors contributed equally to this work

Correspondence to:

Shuwei Huang, email: [email protected]

Keywords: ICAM-1, rs5498, myocardial infarction, meta-analysis

Received: March 20, 2017 Accepted: April 17, 2017 Published: April 29, 2017

ABSTRACT

Several studies addressed the association between Intercellular adhesion molecule 1 (ICAM-1) rs5498 polymorphism and Myocardial Infarction (MI) risk. However, they addressed conflicting findings. Therefore, the aim of this study was to explore whether ICAM-1 gene rs5498 polymorphism plays an important role in modifying the risk of MI. A meta-analysis was conducted on the association between ICAM-1 rs5498 polymorphism and MI. 12 eligible studies involving 1,696 cases and 3,039 controls were included in the meta-analysis. Meta-analysis revealed that ICAM-1 rs5498 polymorphism showed a strongly positive correlation with MI and could be viewed as a protective factor for MI. Furthermore, subgroup analysis according to ethnicity indicated that ICAM-1 rs5498 polymorphism decreased the risk of MI among Caucasian and Asian populations. In conclusion, ICAM-1 rs5498 polymorphism was associated with the decreased risk of MI. Larger sample size studies with more diverse ethnic populations are needed to confirm these findings.

All site content, except where otherwise noted, is licensed under a Creative Commons Attribution 4.0 License.
PII: 17529

Publication Alerts

Research Papers:

Intercellular adhesion molecule 1 rs5498 polymorphism is associated with the risk of myocardial infarction

Abstract