Oncotarget

Meta-Analysis:

Prognostic significance of soluble mesothelin in malignant pleural mesothelioma: a meta-analysis

Long Tian, Rujun Zeng, Xin Wang, Cheng Shen, Yutian Lai, Mingming Wang, Guowei Che _

PDF  |  HTML  |  Order a Reprint

Oncotarget. 2017; 8:46425-46435. https://doi.org/10.18632/oncotarget.17436

Metrics: HTML 907 views  |   ?  


Abstract

Long Tian1,*, Rujun Zeng2,*, Xin Wang1,*, Cheng Shen1, Yutian Lai1, Mingming Wang1 and Guowei Che1

1Department of Thoracic Surgery, West China Hospital, Sichuan University, Chengdu, China

2Department of Obstetrics and Gynecology, West China Second University Hospital, Sichuan University, Chengdu, China

*These authors have contributed equally to this work

Correspondence to:

Guowei Che, email: guowei_che@yahoo.com

Keywords: soluble mesothelin, malignant pleural mesothelioma, prognosis, meta-analysis

Abbreviations: MPM: malignant pleural mesothelioma; CI: confidence interval; HR: hazard ratio

Received: November 30, 2016    Accepted: April 10, 2017    Published: April 26, 2017

ABSTRACT

Background: Soluble mesothelin is beneficial to detect the progression and the treatment response of malignant pleural mesothelioma. However, the prognostic value of soluble mesothelin in malignant pleural mesothelioma remains unclear.

Methods: Hazard ratio with 95% CI was used to evaluate the prognostic value of soluble mesothelin and the effect of clinicopathological characteristics on the survival of malignant pleural mesothelioma.

Results: Eight eligible studies involving 579 patients were selected for this meta-analysis. The results showed that soluble mesothelin level was significantly correlated with the survival of malignant pleural mesothelioma (pooled HR: 1.958, 95%CI: 1.531-2.504, p = 0.000; heterogeneity test: I2 = 1.1%, p = 0.421). In addition, the survival of malignant pleural mesothelioma was significantly correlated with some clinicopathological characteristics such as tumor histology (HR = 3.214, 95% CI = 2.071-4.988, p = 0.000; heterogeneity test: I2 = 0.0%, p = 0.623) and tumor stage (HR = 2.007; 95% CI = 1.477-2.727; p = 0.000; heterogeneity test: I2 = 0.0%, p = 0.966).

Conclusions: The survival of malignant pleural mesothelioma is significantly correlated with tumor histology and tumor stage. Furthermore, high soluble mesothelin level may lead to a poor prognosis for malignant pleural mesothelioma patients.


Creative Commons License All site content, except where otherwise noted, is licensed under a Creative Commons Attribution 3.0 License.
PII: 17436