Oncotarget

Research Papers: Immunology:

A single nucleotide polymorphism in the interferon-γ gene (IFNG +874 T/A) is associated with susceptibility to tuberculosis

Zhang Wei _, Shen Wenhao, Mi Yuanyuan, Li Yang, Zhou Daming, Xian Jiangchun and Jiang Jijun

PDF  |  HTML  |  How to cite  |  Order a Reprint

Oncotarget. 2017; 8:50415-50429. https://doi.org/10.18632/oncotarget.17304

Metrics: PDF 815 views  |   HTML 1352 views  |   ?  


Abstract

Zhang Wei1,*, Shen Wenhao2,*, Mi Yuanyuan3, Li Yang1, Zhou Daming1, Xian Jiangchun1 and Jiang Jijun1

1 Department of Infectious Disease, Taizhou People’s Hospital, Taizhou, China

2 Department of Oncology, Taizhou People’s Hospital, Taizhou, China

3 Department of Urology, Third Affiliated Hospital of Nantong University, Wuxi, China

* These authors have contributed equally to this work

Correspondence to:

Zhang Wei, email:

Keywords: Interferon-γ; pulmonary tuberculosis; extra-pulmonary tuberculosis; polymorphism; meta-analysis; Immunology and Microbiology Section; Immune response; Immunity

Received: January 07, 2017 Accepted: March 30, 2017 Published: April 20, 2017

Abstract

Interferon-γ (Interferon gamma, IFNG) is an important cytokine involved in providing resistance to mycobacterial diseases. Common variants of IFNG, such as IFNG +874 T/A(rs2430561), may be related to tuberculosis susceptibility, but this association has not been consistently observed. We performed an updated meta-analysis to evaluate the association between the IFNG +874 T/A (rs2430561) polymorphism and tuberculosis susceptibility. PubMed and SinoMed databases were searched up to October 2016, and odds ratios (OR) and 95% confidence intervals (CI) were used to assess the association strength. Based on search criteria for manuscripts reporting tuberculosis susceptibility and its relationship with the IFNG +874 T/A(rs2430561)polymorphism, 42 case-control studies from 39 different articles were retrieved. Significantly positive, decreased, and protective associations were found between the IFNG +874 T/A(rs2430561)polymorphism and tuberculosis risk in five genetic models. Moreover, in the stratified subgroup analysis, a protective relationship was detected in four different ethnicities and sources of the control groups. Furthermore, the IFNG +874 T/A(rs2430561)polymorphism played an important role in protecting individuals from both pulmonary tuberculosis and extra-pulmonary tuberculosis. Our meta-analysis suggests that the IFNG +874 T/A(rs2430561)polymorphism is potentially associated with tuberculosis susceptibility and may be used as a predictive biomarker. Further studies with larger sample sizes and consideration of gene-environment interactions should be conducted to elucidate the role of IFNG +874 T/A(rs2430561) polymorphism in tuberculosis susceptibility.


Creative Commons License All site content, except where otherwise noted, is licensed under a Creative Commons Attribution 3.0 License.
PII: 17304