Oncotarget

Meta-Analysis:

Efficacy and safety of different molecular targeted agents based on chemotherapy for gastric cancer patients treatment: a network meta-analysis

Zheng Ren, Jinping Sun, Xinfang Sun, Hongtao Hou, Ke Li and Quanxing Ge _

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Oncotarget. 2017; 8:48253-48262. https://doi.org/10.18632/oncotarget.17192

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Abstract

Zheng Ren1,*, Jinping Sun1,*, Xinfang Sun1, Hongtao Hou1, Ke Li1 and Quanxing Ge1

1Department of Digestive Internal Medicine, Huaihe Hospital of Henan University, Kaifeng 475000, Henan, China

*These authors contributed equally to this work

Correspondence to:

Quanxing Ge, email: hongluojiadoctor@163.com

Keywords: gastric cancer, molecular targeted agents, chemotherapy, network meta-analysis, efficacy

Received: February 09, 2017     Accepted: March 23, 2017     Published: April 18, 2017

ABSTRACT

Increasing numbers of reports have been published to demonstrate that molecular targeted agents are able to improve the efficacy of chemotherapy in gastric cancer. This network meta-analysis aimed to evaluate the efficacy and safety of different molecular targeted agents, which were divided into six groups based on the targets including hepatocyte growth factor receptor (c-MET), vascular endothelial factor and its receptor (VEGF/VEGFR), human epidermal growth factor receptor 2 (HER2), epidermal growth factor receptor (EGFR), mammalian target of rapamycin (mTOR) and tyrosine kinase inhibitor (TKI). These six groups of targeted agents were evaluated for their efficacy outcomes measured by overall survival (OS), progression-free survival (PFS) and overall response rate (ORR). While their safety was measured 7 adverse events, including fatigue, anaemia, vomiting, neutropenia, thrombocytopenia, diarrhea and nausea. A total of 23 articles were included after extensive searching and strict inclusion, HER2 and VEGF(R) turned out to be the two most effective targeted drugs for their outstanding performance in OS and PFS. However, they were associated with severe adverse events, including fatigue, neutropenia and diarrhea. Therefore, they should be used with caution during their application. In conclusion, VEGF(R) and HER2 have the potential to be the optimal target agents for their survival efficacy, while the adverse events associated with them should be paid attention in application.


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