Oncotarget

Research Papers:

Elevated CD147 expression is associated with shorter overall survival in non-small cell lung cancer

Xiaojun Zhang, Tian Tian, Xiaofeng Zhang, Changting Liu _ and Xiangqun Fang

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Oncotarget. 2017; 8:37673-37680. https://doi.org/10.18632/oncotarget.16948

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Abstract

Xiaojun Zhang1, Tian Tian1, Xiaofeng Zhang1, Changting Liu1 and Xiangqun Fang1

1Nanlou Respiratory Diseases Department, Chinese PLA General Hospital, Beijing 100853, P. R. China

Correspondence to:

Changting Liu, email: changtliu@yeah.net

Xiangqun Fang, email: xqfang301@163.com

Keywords: CD147, lung cancer, meta-analysis, prognosis, survival

Received: December 28, 2016     Accepted: March 13, 2017     Published: April 07, 2017

ABSTRACT

A number of studies have reported on the prognostic role of CD147 expression in non-small cell lung cancer (NSCLC); however, the results remain controversial. This study aims to investigate the impact of CD147 on the prognosis of NSCLC by means of a meta-analysis. A literature search was performed for relevant studies published before October 29, 2016. The hazard ratios (HRs), odds ratios (ORs), and 95% confidence intervals (CIs) were calculated as effective measures. Sensitivity analysis and publication bias examination were also conducted. Ten eligible studies with a total of 1605 patients were included in this meta-analysis. CD147 overexpression was correlated with poor overall survival (OS) (HR=1.59, 95% CI=1.32–1.91, p<0.001). Elevated CD147 expression was associated with the presence of lymph node metastasis (OR=2.31, 95% CI=1.74–3.07, p<0.001) and advanced TNM stage (OR=3.03, 95% CI=1.24–7.39, p=0.015). However, no significant association between CD147 and sex, age, differentiation, or histology was found. No evidence of significant publication bias was identified. This meta-analysis revealed that overexpression of CD147 was associated with shorter OS, the presence of lymph node metastasis and advanced TNM stage in NSCLC. Therefore, CD147 could serve as a potential prognostic marker for NSCLC.


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