Oncotarget

Research Papers:

Associations between LMO1 gene polymorphisms and Wilms’ tumor susceptibility

Guo-Chang Liu, Zhen-Jian Zhuo, Shi-Bo Zhu, Jinhong Zhu, Wei Jia, Zhang Zhao, Jin-Hua Hu, Jing He, Feng-Hua Wang and Wen Fu _

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Oncotarget. 2017; 8:50665-50672. https://doi.org/10.18632/oncotarget.16926

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Abstract

Guo-Chang Liu1,*, Zhen-Jian Zhuo2,*, Shi-Bo Zhu1, Jinhong Zhu3, Wei Jia1, Zhang Zhao1, Jin-Hua Hu1, Jing He1, Feng-Hua Wang1 and Wen Fu1

1Department of Pediatric Urology, Department of Pediatric Surgery, Guangzhou Institute of Pediatrics, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou 510623, Guangdong, China

2School of Chinese Medicine, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong 999077, China

3Molecular Epidemiology Laboratory and Department of Laboratory Medicine, Harbin Medical University Cancer Hospital, Harbin 150040, Heilongjiang, China

*These authors contributed equally to this work

Correspondence to:

Wen Fu, email: lydia_fw@hotmail.com

Feng-Hua Wang, email: wangfhua@163.com

Keywords: LMO1,Wilms’ tumor, polymorphism, susceptibility, GWAS

Received: January 17, 2017     Accepted: March 22, 2017     Published: April 07, 2017

ABSTRACT

Wilms’ tumor is the most common childhood renal malignancy. A genome-wide association study identified LIM domain only 1 (LMO1) as having oncogenic potential. We examined the associations between LMO1 gene polymorphisms and susceptibility to Wilms’ tumor. In this hospital-based, case-control study, we recruited 145 children with Wilms’ tumor and 531 cancer-free children. Four polymorphisms (rs110419 A>G, rs4758051 G>A, rs10840002 A>G and rs204938 A>G) were genotyped using Taqman methodology. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated to measure the associations between selected polymorphisms and Wilms’ tumor susceptibility. Only rs110419 AG was found to be protective against Wilms’ tumor (adjusted OR = 0.62, 95% CI = 0.41–0.94, P = 0.024) when compared to rs110419 AA. Wilms’ tumor risk was markedly greater in children with 1–4 risk genotypes (nucleotide alterations) than in those with no risk genotypes (adjusted OR = 1.84, 95% CI = 1.25–2.69, P = 0.002). In a stratified analysis, the protective effect of rs110419 AG/GG was predominant in males. The association of 1–4 risk genotypes with Wilms’ tumor risk was limited to subgroups of children who were >18 months old, female, and in clinical stages III+IV. Thus, LMO1 gene polymorphisms may contribute to Wilms’ tumor risk, but this conclusion should be validated in other populations and larger studies.


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