Oncotarget

Meta-Analysis:

Tea consumption and the risk of ovarian cancer: A meta-analysis of epidemiological studies

Xin Zhan, Jie Wang, Shufen Pan and Caijuan Lu _

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Oncotarget. 2017; 8:37796-37806. https://doi.org/10.18632/oncotarget.16890

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Abstract

Xin Zhan1,*, Jie Wang2,*, Shufen Pan3, Caijuan Lu1

1Obstetrics and Gynecology Department, Hangzhou First People’s Hospital, Hangzhou, Zhejiang 310006, PR China

2Obstetrics and Gynecology Department, The First Affiliated Hospital of Zhejiang Chinese Medical University Zhejiang Provincial Hospital of TCM, Hangzhou, Zhejiang 310016, PR China

3Department of Obstetrics and Gynecology, Central Hospital of Wenzhou, Luchengqu, Wenzhou, Zhejiang 325000, PR China

*These authors contributed equally to this work

Correspondence to:

Caijuan Lu, email: goaltarget@163.com

Keywords: ovarian cancer, tea, meta-analysis

Received: November 08, 2016     Accepted: March 27, 2017     Published: April 06, 2017

ABSTRACT

A large number of epidemiological studies have provided conflicting results about the relationship between tea consumption and ovarian cancer. This study aimed to clarify the association between tea consumption and ovarian cancer. A literature search of the MEDICINE, Scopus, PubMed, and Web of Science databases was performed in April 2016. A total of 18 (11 case-control and 7 cohort) studies, representing data for 701,857 female subjects including 8,683 ovarian cancer cases, were included in the meta-analysis. A random-effects meta-analysis was used to compute the pooled relative risks (RR), meta regression, and publication bias, and heterogeneity analyses were performed for the included trials. We found that tea consumption had a significant protective effect against ovarian cancer (relative risk [RR] = 0.86; 95% confidence interval [CI]: 0.76, 0.96). The relationship was confirmed particularly after adjusting for family history of cancer (RR = 0.85; 95% CI: 0.72, 0.97), menopause status (RR = 0.85; 95% CI: 0.72, 0.98), education (RR = 0.82; 95% CI: 0.68, 0.96), BMI (RR = 0.85; 95% CI: 0.70, 1.00) , smoking (RR = 0.83; 95% CI: 0.72, 0.93) and Jadad score of 3 (RR = 0.76; 95% CI: 0.56, 0.95) and 5 (RR = 0.74; 95% CI: 0.59, 0.89). The Begg’s and Egger’s tests (all P > 0.01) showed no evidence of publication bias. In conclusion, our meta-analysis showed an inverse association between tea consumption and ovarian cancer risk. High quality cohort-clinical trials should be conducted on different tea types and their relationship with ovarian cancer.


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PII: 16890