Oncotarget

Reviews:

SNM1B/Apollo in the DNA damage response and telomere maintenance

Maren Schmiester and Ilja Demuth _

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Oncotarget. 2017; 8:48398-48409. https://doi.org/10.18632/oncotarget.16864

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Abstract

Maren Schmiester1,2 and Ilja Demuth1,2,3

1Lipid Clinic at the Interdisciplinary Metabolism Center, Charité-Universitätsmedizin Berlin, 13353 Berlin, Germany

2Institute of Medical and Human Genetics, Charité–Universitätsmedizin Berlin, 13353 Berlin, Germany

3Research Group on Geriatrics, Charité–Universitätsmedizin Berlin, 13347 Berlin, Germany

Correspondence to:

Ilja Demuth, email: ilja.demuth@charite.de

Keywords: Apollo, hSNM1B, DCLRE1B, Fanconi anemia

Received: February 21, 2017     Accepted: March 27, 2017     Published: April 05, 2017

ABSTRACT

hSNM1B/Apollo is a member of the highly conserved β-CASP subgroup within the MBL superfamily of proteins. It interacts with several DNA repair proteins and functions within the Fanconi anemia pathway in response to DNA interstrand crosslinks. As a shelterin accessory protein, hSNM1B/Apollo is also vital for the generation and maintenance of telomeric overhangs. In this review, we will summarize studies on hSNM1B/Apollo's function, including its contribution to DNA damage signaling, replication fork maintenance, control of topological stress and telomere protection. Furthermore, we will highlight recent studies illustrating hSNM1B/Apollo’s putative role in human disease.


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