Genetic variants within the cancer susceptibility region 8q24 and ovarian cancer risk in Han Chinese women

Jing Han; Jing Zhou; Hua Yuan; Longbiao Zhu; Hongxia Ma; Dong Hang; Dake Li

doi:10.18632/oncotarget.16861

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Research Papers:

Genetic variants within the cancer susceptibility region 8q24 and ovarian cancer risk in Han Chinese women

Jing Han, Jing Zhou, Hua Yuan, Longbiao Zhu, Hongxia Ma, Dong Hang and Dake Li _

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Oncotarget. 2017; 8:36462-36468. https://doi.org/10.18632/oncotarget.16861

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Abstract

Jing Han1,2, Jing Zhou1,3, Hua Yuan4, Longbiao Zhu4, Hongxia Ma1,3, Dong Hang1,3, Dake Li5

1Department of Epidemiology and Biostatistics, School of Public Health, Nanjing Medical University, Nanjing 211166, China

2Department of Epidemiology, Nanjing Medical University Affiliated Cancer Institute of Jiangsu Province, Nanjing 211166, China

3State Key Laboratory of Reproductive Medicine, Nanjing Medical University, Nanjing 211166, China

4Jangsu Key Laboratory of Oral Disease, Nanjing Medical University, Nanjing 210029, China

5Department of Gynaecology, Jiangsu Provincial Hospital of TCM, Affiliated Hospital of Nanjing University of TCM, Nanjing 210005, China

Correspondence to:

Dong Hang, email: [email protected]

Dake Li, email: [email protected]

Keywords: ovarian cancer, Han Chinese women, 8q24 region, variant

Received: December 28, 2016 Accepted: March 28, 2017 Published: April 05, 2017

ABSTRACT

Accumulating evidence suggests that genetic variants at chromosome 8q24 confer susceptibility to various types of cancer. This case-control study was designed to explore the relationship between genetic variants at 8q24 and ovarian cancer risk in Han Chinese women. Two variants (rs13281615 A > G and rs6983267 T > G) were genotyped in 377 ovarian cancer cases and 1034 cancer-free controls using TaqMan allelic discrimination assay. Logistic regression analysis revealed that the G allele of rs6983267 was significantly associated with increased risk of ovarian cancer (additive model: adjusted OR = 1.21, 95% CI = 1.01–1.43, P = 0.048; recessive model: adjusted OR = 1.51, 95% CI = 1.06–2.15, P = 0.023). However, no significant association was observed between rs13281615 and ovarian cancer. In stratified analysis, the risk effect of rs6983267 variant remained significant in premenopausal women (additive model: adjusted OR = 1.62, 95% CI = 1.18–2.23, P = 0.003). Summarily, this study suggested that 8q24 rs6983267 may contribute to the susceptibility of ovarian cancer in premenopausal Han Chinese women, supporting the pleiotropy of 8q24 in carcinogenesis.

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Research Papers:

Genetic variants within the cancer susceptibility region 8q24 and ovarian cancer risk in Han Chinese women

Abstract