Experimental study of brachial plexus and vessel compression: evaluation of combined central and peripheral electrodiagnostic approach

Chaoqun Yang; Jianguang Xu; Jie Chen; Shulin Li; Yu Cao; Yi Zhu; Lei Xu

doi:10.18632/oncotarget.16817

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Research Papers:

Experimental study of brachial plexus and vessel compression: evaluation of combined central and peripheral electrodiagnostic approach

Chaoqun Yang, Jianguang Xu, Jie Chen, Shulin Li, Yu Cao, Yi Zhu and Lei Xu _

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Oncotarget. 2017; 8:50618-50628. https://doi.org/10.18632/oncotarget.16817

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Abstract

Chaoqun Yang1, Jianguang Xu1, Jie Chen1, Shulin Li1, Yu Cao1, Yi Zhu1 and Lei Xu1

1Department of Hand Surgery, Huashan Hospital, Fudan University, Shanghai, China

Correspondence to:

Lei Xu, email: [email protected]

Keywords: brachial plexus, electrodiagnosis, electrophysiology, experimental study

Received: January 23, 2017 Accepted: March 09, 2017 Published: April 04, 2017

ABSTRACT

Introduction: We sought to investigate the reliability of a new electrodiagnostic method for identifying Electrodiagnosis of Brachial Plexus & Vessel Compression Syndrome (BPVCS) in rats that involves the application of transcranial electrical stimulation motor evoked potentials (TES-MEPs) combined with peripheral nerve stimulation compound muscle action potentials (PNS-CMAPs).

Results: The latencies of the TES-MEP and PNS-CMAP were initially elongated in the 8-week group. The amplitudes of TES-MEP and PNS-CMAP were initially attenuated in the 16-week group. The isolateral amplitude ratio of the TES-MEP to the PNS-CMAP was apparently decreased, and spontaneous activities emerged at 16 weeks postoperatively.

Materials and Methods: Superior and inferior trunk models of BPVCS were created in 72 male Sprague Dawley (SD) rats that were divided into six experimental groups. The latencies, amplitudes and isolateral amplitude ratios of the TES-MEPs and PNS-CMAPs were recorded at different postoperative intervals.

Conclusions: Electrophysiological and histological examinations of the rats’ compressed brachial plexus nerves were utilized to establish preliminary electrodiagnostic criteria for BPVCS.

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Research Papers:

Experimental study of brachial plexus and vessel compression: evaluation of combined central and peripheral electrodiagnostic approach

Abstract