Oncotarget

Research Papers:

Comparative study of joint bioinformatics analysis of underlying potential of ‘neurimmiR’, miR-212-3P/miR-132-3P, being involved in epilepsy and its emerging role in human cancer

Lu Xia, Daojiang Li, Changwei Lin, Shuchun Ou, Xiaorong Li and Songqing Pan _

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Oncotarget. 2017; 8:40668-40682. https://doi.org/10.18632/oncotarget.16541

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Abstract

Lu Xia1,*, Daojiang Li2,*, Changwei Lin2,3, Shuchun Ou1, Xiaorong Li2,3 and Songqing Pan1

1Department of Neurology, Renmin Hospital of Wuhan University, Wuhan 430060, Hubei Provinces, China

2Department of General Surgery, The Third XiangYa Hospital of Central South University, Changsha, Hunan 410013, China

3Center for Experimental Medicine, The Third XiangYa Hospital of Central South University, Changsha, Hunan 410013, China

*Shared first authors

Correspondence to:

Songqing Pan, email: psq@medmail.com.cn

Xiaorong Li, email: lixiaorong@medmail.com.cn

Keywords: miR-132, miR-212, epilepsy, cancer, tumor-induced epileptogenesis

Received: December 20, 2016    Accepted: February 20, 2017    Published: March 24, 2017

ABSTRACT

Considering the critical roles of miR-132/212 participated in central nervous system, many researches started to explored the contributions of miR-132/212 to epilepsy and achieve something worthwhile. Further illuminates all the genes targeted by miR-132/212 may be a valuable means for us to completely understand the working mechanism playing in epilepsy, by which it can influence diverse biological process. This study attempts to establish macrocontrol regulation system and knowledge that miR-212-3p/132-3p effected the epilepsy, for this literature search, miRbase, Vienna RNAfold webserver, Human miRNA tissue atlas, DIANA-TarBase, miRtarbase, STRING, TargetScanhuman, Cytoscape plugin ClueGO + Cluepedia+STRING, DAVID Bioinformatics Resources, Starbase, GeneCards suite and GEO database are comprehensive employed, miR-132-3p/212-3p and its target gene were found have highly expressed in brain and lots of molecular function and metabolic pathways associated with epilepsy may be intervened by it. Meanwhile, the emerging role of miR-132-3p/212-3p being involved in human cancer also been analyzed by several webtools for TCGA data integrative analysis, most remarkably and well worth exploring in our research conclusion that showed miR-132-3p/212-3p may be the core molecular underlying tumor-induced epileptogenesis.


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