Oncotarget

Clinical Research Papers:

Prognostic scores based on the preoperative plasma fibrinogen and serum albumin level as a prognostic factor in patients with upper urinary tract urothelial carcinoma

Jianfeng Cui, Meng Yu, Ning Zhang, Shiyu Wang, Yaofeng Zhu, Shouzhen Chen, Kejia Zhu, Jian Du, Hongda Zhao, Xigao Liu, Pengxiang Chen, Wenbo Wang, Dongqing Zhang and Benkang Shi _

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Oncotarget. 2017; 8:68964-68973. https://doi.org/10.18632/oncotarget.16483

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Abstract

Jianfeng Cui1, Meng Yu1, Ning Zhang1, Shiyu Wang1, Yaofeng Zhu1, Shouzhen Chen1, Kejia Zhu1, Jian Du1, Hongda Zhao1, Xigao Liu1, Pengxiang Chen2, Wenbo Wang3, Dongqing Zhang1 and Benkang Shi1

1 Department of Urology, Qilu Hospital of Shandong University, Jinan, P.R. China

2 Department of Radiation Oncology, Qilu Hospital, Shandong University, Jinan, P.R. China

3 School of Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, P.R. China

Correspondence to:

Benkang Shi, email:

Dongqing Zhang, email:

Keywords: upper urinary tract urothelial carcinoma; plasma fibrinogen; serum albumin; prognosis

Received: December 29, 2016 Accepted: March 15, 2017 Published: March 22, 2017

Abstract

This study is to clarify the prognostic value of preoperative plasma fibrinogen and serum albumin level, as known as FA score, in a cohort of Chinese patients with upper urinary tract urothelial carcinoma (UTUC). We retrospectively evaluated clinicopathological data on 169 patients who underwent surgery between 2006 and 2013. The FA score was calculated based on cutoff values of 3.53g/L for fibrinogen and 43.56 g/L for albumin. Overall survival and cancer specific survival was assessed using the Kaplan-Meier method and the equivalences of the curves were tested by log-rank tests. The Cox proportional hazards regression model was applied in univariate and multivariate analyses. In univariate analysis, tumor size, tumor grade, pathological T stage and FA score were significantly associated with overall survival and cancer specific survival, and multivariate Cox proportional hazards regression analysis identified FA score (score 1: HR=3.486, 95%CI 1.358-8.948, p=0.009; HR=3.485, 95%CI 1.363-8.913, p=0.009, respectively; score 2: HR=5.509, 95%CI 2.144-14.158, p<0.001; HR=5.521, 95%CI 2.074-14.697, p=0.001, respectively) was an independent predictor for overall survival and cancer specific survival. The evaluation of preoperative FA score can be regarded as an independent prognostic factor for predicting overall survival and cancer specific survival in UTUC. The fibrinogen and albumin levels are low cost and easy accessibility in clinical practice.


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