Oncotarget

Clinical Research Papers:

Individual isotoxic radiation dose escalation based on V20 and advanced technologies benefits unresectable stage III non-small cell lung cancer patients treated with concurrent chemoradiotherapy: long term follow-up

Ming Liu, Zhongtang Wang, Tao Zhou, Antang Zhou, Qian Zhao, Hongsheng Li, Hongfu Sun, Wei Huang and BaoSheng Li _

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Oncotarget. 2017; 8:51848-51858. https://doi.org/10.18632/oncotarget.16288

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Abstract

Ming Liu1,2,*, Zhongtang Wang2,*, Tao Zhou2, Antang Zhou3, Qian Zhao2, Hongsheng Li2, Hongfu Sun2, Wei Huang2 and BaoSheng Li2,4

1 School of Medicine and Life Sciences, University of Jinan-Shandong Academy of Medical Sciences, Jinan, Shandong, P.R. China

2 Department of Radiation Oncology, Shandong Cancer Hospital Affiliated to Shandong University, Shandong Academy of Medical Sciences, Jinan, Shandong, P.R. China

3 Department of General Surgery, Yanggu People’s Hospital, Liaocheng, Shandong, P.R. China

4 Engineering Research Center for Medical Imaging and Radiation Therapy of Shandong Province, Jinan, Shandong, P.R. China

* These authors have contributed equally to this study and should be considered as co-first authors

Correspondence to:

BaoSheng Li, email:

Keywords: non-small cell lung cancer, chemoradiotherapy, lung V20, Individual isotoxic dose escalation, advanced radiotherapy technologies

Received: September 30, 2016 Accepted: March 09, 2017 Published: March 16, 2017

Abstract

Under the assumption that the highest therapeutic ratio could be achieved by increasing the total tumor dose (TTD) to the limits of normal tissues, the phase I trial was conducted in patients with unresectable stage III non-small cell lung cancer treated with concurrent chemoradiotherapy, to determine the feasibility and effects of individual isotoxic radiation dose escalation based on bilateral lung V20 and advanced technologies. Consecutive eligible patients were assigned to cohorts of eight. V20 of each cohort was increased from 27% to 30%, 33%, 35%, 37%, and so on. The criterion for cessation of dose escalation was defined as ≥ 2 patients in each cohort experienced dose limiting toxicity. Isotoxic dose escalation was based on V20, functional imaging was used to improve the accuracy of radiotherapy. To test the power of escalation dose, patients with TTD over 66 Gy were assigned to the higher dose group (HD), while the others to the standard dose one (SD). In result, the recommended value of V20 was 35%. For all patients, follow-up ranged from 1 to 112 months, median overall and progression free survivals were 25.0 and 13.0 months, respectively. The 1-, 3-, 5- and 8-year overall survival (OS) rates were 72.5%, 22.5%, 17.5%, and 10.0%, respectively. Especially, the OS and local recurrence-free survival of patients in HD group were significantly longer than those in SD one (P=0.035, P=0.007, respectively) without increasing severe toxicity. Thus, individual isotoxic dose escalation based on V20 with advanced technologies was feasible and effective.


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