Effects of CD20+ B-cell infiltration into allografts on kidney transplantation outcomes: a systematic review and meta-analysis

Yingying Lu; Bingjue Li; Qixia Shen; Rending Wang; Zhimin Chen; Hong Jiang; Jianghua Chen

doi:10.18632/oncotarget.16229

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Effects of CD20+ B-cell infiltration into allografts on kidney transplantation outcomes: a systematic review and meta-analysis

Yingying Lu, Bingjue Li, Qixia Shen, Rending Wang, Zhimin Chen, Hong Jiang and Jianghua Chen _

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Oncotarget. 2017; 8:37935-37941. https://doi.org/10.18632/oncotarget.16229

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Abstract

Yingying Lu1,*, Bingjue Li1,*, Qixia Shen1, Rending Wang1, Zhimin Chen1, Hong Jiang1 and Jianghua Chen1

1 Kidney Disease Center, The First Affiliated Hospital, College of Medicine, Zhejiang University, 310003, P.R. China

* These authors have contributed equally to this work

Correspondence to:

Jianghua Chen, email:

Hong Jiang, email:

Keywords: CD20+ B cell, kidney transplantation, acute rejection, graft loss, steroid resistance

Received: September 23, 2016 Accepted: March 04, 2017 Published: March 15, 2017

Abstract

The effects of CD20+ B-cell infiltration during acute rejection on graft outcomes are controversial. The objective of this systematic review and meta-analysis was to clarify this issue. We performed a systematic literature search for studies published up to January 14, 2016. A total of 5 studies, with 200 patients, were included. The presence of CD20+ B cells in renal biopsies during allograft rejection was associated with graft loss and steroid resistance. No association of CD20+ B-cell infiltration with C4d-positive staining of the peritubular capillaries in renal biopsies was found in the analysis of patients who experienced kidney graft rejection. In conclusion, CD 20+ B cell infiltration during allograft rejection was associated with an increased risk of graft loss and steroid resistance.

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Effects of CD20+ B-cell infiltration into allografts on kidney transplantation outcomes: a systematic review and meta-analysis

Abstract