Oncotarget

Research Papers:

Impact of statins therapy on morphological changes in lipid-rich plaques stratified by 10-Year framingham risk score: A serial optical coherence tomography study

Yinchun Zhu, Lin Lin, Chao Wang, Haibo Jia, Sining Hu, Lulu Li, Xiling Zhang, Gonghui Zheng, Yan Wang, Rong Sun, Abigail Afolabi, Irina Mustafina, Jingbo Hou, Shaosong Zhang and Bo Yu _

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Oncotarget. 2017; 8:27401-27411. https://doi.org/10.18632/oncotarget.16172

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Abstract

Yinchun Zhu1,*, Lin Lin1,*, Chao Wang1,*, Haibo Jia1, Sining Hu1, Lulu Li1, Xiling Zhang1, Gonghui Zheng1, Yan Wang1, Rong Sun1, Abigail Afolabi1, Irina Mustafina1, Jingbo Hou1, Shaosong Zhang2, Bo Yu1

1Department of Cardiology, The Second Affiliated Hospital of Harbin Medical University, The Key Laboratory of Myocardial Ischemia, Chinese Ministry of Education, Harbin, China

2Department of Cardiology, The Second Affiliated Hospital of Harbin Medical University, Harbin, China

*These authors have contributed equally to this work

Correspondence to:

Bo Yu, email: yubodr@163.com

Haibo Jia, email: jhb101180@163.com

Keywords: statins therapy, morphological changes, lipid-rich plaques, framingham risk score, optical coherence tomography

Received: August 24, 2016     Accepted: January 16, 2017     Published: March 14, 2017

ABSTRACT

The aim of the study was to investigate the impact of statins therapy on morphological changes of lipid-rich plaques by OCT (optical coherence tomography) in patients with known CHD (coronary heart disease), stratified by FRS. Ninety-seven lipid-rich plaques from sixty-nine patients who received statins therapy and underwent serial OCT images (baseline, 6-month and 12-month) were divided into 2 groups according to the FRS (framingham risk score): low risk group A (FRS<10%, N=35, n=45), moderate to high risk group B (FRS≥10%, N=34, n=52). Fibrous cap thickness (FCT) was measured at its thinnest part 3 times. Baseline characteristics were not different between the 2 groups. FCT sustained increased from baseline to 6-month and 12-month follow up in both group A (59.8±20.4μm, 118.3±62.5μm, and 158.8±83.4μm respectively, P<0.001) and group B (62.2±16.8μm, 125.1±78.7μm, 163.8±75.5μm respectively, P<0.001). Lipid index was significantly decreased in both group A (1862.1±1164.5, 1530.3±1108.7, 1322.9±1080.4, P<0.001) and group B (1646.6±958.5, 1535.1±1049.1, 1258.6±1045, P=0.016). The incidence of TCFA was decreased statistically in both group A (P <0.001) and group B (P <0.001). The patients with known CHD can equivalently benefit from statins therapy by stabilizing the lipid-rich plaques. Patients with moderate to high FRS might benefit more within the first year from event time.


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