Laminarin promotes anti-cancer immunity by the maturation of dendritic cells

Kyeongeun Song; Li Xu; Wei Zhang; Yun Cai; Bian Jang; Junghwan Oh; Jun-O Jin

doi:10.18632/oncotarget.16170

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Research Papers:

Laminarin promotes anti-cancer immunity by the maturation of dendritic cells

Kyeongeun Song, Li Xu, Wei Zhang, Yun Cai, Bian Jang, Junghwan Oh and Jun-O Jin _

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Oncotarget. 2017; 8:38554-38567. https://doi.org/10.18632/oncotarget.16170

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Abstract

Kyeongeun Song1,2,*, Li Xu1,*, Wei Zhang1, Yun Cai1, Bian Jang1,2,3,4, Junghwan Oh2,3,4 and Jun-O Jin1

1Shanghai Public Health Clinical Center, Shanghai Medical College, Fudan University, Shanghai, 201508, China

2Marine-Integrated Bionics Research Center, Pukyong National University, Busan, 48513, Korea

3Department of Biomedical Engineering and Center for Marine-Integrated Biomedical Technology (BK21 Plus), Pukyong National University, Busan, 48513, Korea

4Interdisciplinary Program of Biomedical Mechanical and Electrical Engineering, Pukyong National University, Busan, 48513, Korea

*These authors have contributed equally to this work

Correspondence to:

Jun-O Jin, email: [email protected]

Keywords: laminarin, adjuvant, anti-cancer, dendritic cell maturation, cytotoxic lymphocyte activation

Received: December 28, 2016 Accepted: February 20, 2017 Published: March 14, 2017

ABSTRACT

This research evaluates the effects of laminarin on the maturation of dendritic cells and on the in vivo activation of anti-cancer immunity. In vivo treatment of C56BL/6 mice with laminarin increased the expression levels of co-stimulatory molecules and the production of pro-inflammatory cytokines in spleen dendritic cells. Laminarin enhanced ovalbumin antigen presentation in spleen dendritic cells and promoted the proliferation of OT-I and OT-II T cells. Laminarin also induced the maturation of dendritic cells in tumor-draining lymph nodes and protected interferon-γ and tumor necrosis factor-α and proliferation of OT-I and OT-II T cells in tumors. The combination treatment of laminarin and ovalbumin inhibited B16-ovallbumin melanoma tumor growth and its liver metastasis by antigen-specific immune activation, including cytotoxic T lymphocyte activation and interferon-γ production. Thus, these data demonstrated the potential of laminarin as a new and useful immune stimulatory molecule for use in cancer immunotherapy.

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Research Papers:

Laminarin promotes anti-cancer immunity by the maturation of dendritic cells

Abstract