Oncotarget

Research Papers:

Single nucleotide polymorphism rs3124599 in Notch1 is associated with the risk of lung cancer in northeast Chinese non-smoking females

Xiaowei Quan, Zhihua Yin, Xue Fang and Baosen Zhou _

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Oncotarget. 2017; 8:31180-31186. https://doi.org/10.18632/oncotarget.16101

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Abstract

Xiaowei Quan1,2, Zhihua Yin1,2, Xue Fang1,2, Baosen Zhou1,2

1Department of Epidemiology, School of Public Health, China Medical University, Shenyang, China

2Key Laboratory of Cancer Etiology and Prevention, China Medical University, Liaoning Provincial Department of Education, Liaoning, China

Correspondence to:

Baosen Zhou, email: bszhou@cmu.edu.cn

Keywords: Notch1, single nucleotide polymorphisms, lung cancer, small cell lung cancer, non-smoking females

Received: October 19, 2016     Accepted: March 01, 2017     Published: March 10, 2017

ABSTRACT

Lung cancer is one of the most common cancers and the main cause of cancer-related deaths. Notch1 might play a part in tumorigenesis of lung cancer. Here we explored the relationship of three SNPs (rs3124599, rs3124607 and rs3124594) in Notch1 with the risk and the survival of lung cancer in non-smoking females, including 556 cases and 395 controls. Chi-square tests, logistic regression analysis and crossover analysis were conducted to estimate the association between SNPs and the risk of lung cancer and the interaction between SNPs and environmental exposure. Survival analysis was conducted to explore the association between SNPs and survival of lung cancer. The results demonstrated that the polymorphism of rs3124599 was associated with the susceptibility of lung cancer in recessive model (AA+AG vs. GG). Compared to the those with AA or AG genotype, individuals with GG genotype had a 1.562-fold increased risk of lung cancer (P = 0.023, OR = 1.562, 95% CI = 1.062-2.297). In stratified analysis, the GG genotype of rs3124599 would increase the risk of small cell lung cancer (SCLC) (P = 0.011, OR = 2.167, 95% CI = 1.193-3.396). However, no significant interaction between rs3124599 and cooking oil fume exposure was observed either in addictive model or multiplicative model. The results of survival analysis showed there was no significant association between SNPs and prognosis of lung cancer (P = 0.949 for rs3124599, P = 0.508 for rs3124607, P = 0.884 for rs3124594). Our study might indicate that rs312599 in Notch1 may be a novel biomarker for SCLC risk in Chinese non-smoking females


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