A reproducible model of intramedullary spinal cord tumor in rats bearing RG2 cells

Yuandong Zhuang; Wei Zhao; Weiqiang Zhang; Hao Wei; Xinming Huang; Gangfeng Cai; Chaofeng Fu; Chunhua Wang; Rui Wang; Songsheng Shi; Weizhong Yang; Chunmei Chen

doi:10.18632/oncotarget.16045

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Research Papers:

A reproducible model of intramedullary spinal cord tumor in rats bearing RG2 cells

Yuandong Zhuang, Wei Zhao, Weiqiang Zhang, Hao Wei, Xinming Huang, Gangfeng Cai, Chaofeng Fu, Chunhua Wang, Rui Wang, Songsheng Shi, Weizhong Yang and Chunmei Chen _

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Oncotarget. 2017; 8:30971-30977. https://doi.org/10.18632/oncotarget.16045

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Abstract

Yuandong Zhuang1,*, Wei Zhao1,*, Weiqiang Zhang1, Hao Wei1, Xinming Huang2, Gangfeng Cai1, Chaofeng Fu1, Chunhua Wang1, Rui Wang1, Songsheng Shi1, Weizhong Yang1, Chunmei Chen1

1Department of Neurosurgery, Affiliated Union Hospital of Fujian Medical University, Fuzhou, China

2Department of Medical Imaging, Affiliated Union Hospital of Fujian Medical University, Fuzhou, China

*These authors contributed equally to this work

Correspondence to:

Chunmei Chen, email: [email protected], [email protected]

Keywords: intramedullary spinal cord glioma, animal model, RG2 glioma

Received: January 25, 2017 Accepted: February 28, 2017 Published: March 09, 2017

ABSTRACT

Intramedullary spinal cord tumors (IMSCTs) are lethal diseases to many patients. The lack of adequate animal model has hampered the development of novel treatments. In the current study, a rodent intramedullary glioma model is established to study IMSCT progression. Fischer 344 rats received a intramedullary implantation of RG2 glioma cells. The neurological state of each rat was evaluated on daily basis using the Basso, Beattie and Bresnahan (BBB) scale. Rats implanted with RG2 cells developed significant hind limb paraplegia 20 days after implantation. Magnetic resonance imaging (MRI) scans after three weeks revealed significant intramedullary RG2 tumors in the rats. Forty days post implantation, rats were sacrificed for histopathological examination. Neuro-imaging and HE staining cross sections confirmed intramedullary RG2 glioma cells invading to the spinal cord. Thus, our model displayed many of the same invasive characteristics as human IMSCTs. This model should be a reliable and reproducible methodology to correlate well with the features of human IMSCT.

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Research Papers:

A reproducible model of intramedullary spinal cord tumor in rats bearing RG2 cells

Abstract