Effect of radiotherapy after breast-conserving surgery in older patients with early breast cancer and breast ductal carcinoma  in situ : a meta-analysis

Xuan-zhang Huang; You Chen; Wen-jun Chen; Xi Zhang; Cong-cong Wu; Chao-ying Zhang; Shuang-shuang Sun; Jian Wu

doi:10.18632/oncotarget.15998

Oncotarget

Oncotarget (a primarily oncology-focused, peer-reviewed, open access journal) aims to maximize research impact through insightful peer-review; eliminate borders between specialties by linking different fields of oncology, cancer research and biomedical sciences; and foster application of basic and clinical science.

Its scope is unique. The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. The term was introduced in the inaugural Editorial, Introducing Oncotarget.

As of January 1, 2022, Oncotarget has shifted to a continuous publishing model. Papers will now be published continuously within yearly volumes in their final and complete form and then quickly released to Pubmed.

Subscribe to receive alerts once a paper has been published by Oncotarget.

Impact Journals, LLC is the publisher of Oncotarget: www.impactjournals.com.

Impact Journals is a member of the Wellcome Trust List of Compliant Publishers.

Impact Journals is a member of the Society for Scholarly Publishing.

On December 23, 2022, Oncotarget server experienced a DDoS attack. As a result, Oncotarget site was inaccessible for a few hours. Oncotarget team swiftly dealt with the situation and took it under control. This malicious action will be reported to the FBI.

Research Papers:

Effect of radiotherapy after breast-conserving surgery in older patients with early breast cancer and breast ductal carcinoma in situ: a meta-analysis

Xuan-zhang Huang, You Chen, Wen-jun Chen, Xi Zhang, Cong-cong Wu, Chao-ying Zhang, Shuang-shuang Sun and Jian Wu _

PDF | HTML | How to cite

Oncotarget. 2017; 8:28215-28225. https://doi.org/10.18632/oncotarget.15998

Metrics: PDF 1696 views | HTML 2540 views | ?

Abstract

Xuan-zhang Huang1,*, You Chen2,*, Wen-jun Chen1, Xi Zhang1, Cong-cong Wu1, Chao-ying Zhang1, Shuang-shuang Sun1, Jian Wu1

1 Department of Chemotherapy and Radiotherapy, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou City 325027, P.R. China

2 The Wenzhou Dental Hospital, Wenzhou City 325027, P.R. China

*These authors contributed equally to this work

Correspondence to:

Jian Wu, email: [email protected].

Keywords: radiotherapy, breast-conserving surgery, older, early breast cancer, breast ductal carcinoma in situ

Received: October 22, 2016 Accepted: February 28, 2017 Published: March 08, 2017

ABSTRACT

Background: There are no consistent agreements on whether radiotherapy after breast-conserving surgery (BCS) could provide local control and survival benefit for older patients with early breast cancer or breast ductal carcinoma in situ (DCIS). The present study aimed to evaluate the efficacy of radiotherapy after BCS in older patients with early breast cancer or DCIS.

Results: Radiotherapy could reduce the risk of local relapse in older patients with early breast cancer. The 5-year AR of local relapse was 2.2% and 6.2% for radiotherapy and non-radiotherapy group, respectively, with low 5-year ARD of 4.0% and high NNT of 25. The 10-year AR of local relapse was 5.3% and 10.5% for radiotherapy and non-radiotherapy group, respectively, with the 10-year ARD of 5.2% and NNT of 20. However, radiotherapy could not improve survival benefits, including overall survival, cancer-specific survival, breast-cancer-specific survival, and distant relapse. Moreover, radiotherapy could reduce the risk of ipsilateral breast events in older patients with DCIS.

Materials and Methods: PubMed and Embase database were searched for relevant studies. Hazard ratios (HRs), risk ratios (RRs), absolute risk (AR), absolute risk difference (ARD), and number needed to treat (NNT) were used as effect measures to evaluate the efficacy of radiotherapy in older patients.

Conclusions: Our study indicates that radiotherapy could slightly reduce the risk of local relapse in older patients with favorable early breast cancer. However, radiotherapy cannot translate into significant survival benefits.

All site content, except where otherwise noted, is licensed under a Creative Commons Attribution 4.0 License.
PII: 15998

Publication Alerts

Research Papers:

Effect of radiotherapy after breast-conserving surgery in older patients with early breast cancer and breast ductal carcinoma in situ: a meta-analysis

Abstract