Paraoxonase 1 gene polymorphisms are associated with an increased risk of breast cancer in a population of Chinese women

Junrong Wu; Min Fang; Xiaoping Zhou; Bo Zhu; Zhi Yang

doi:10.18632/oncotarget.15911

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Research Papers:

Paraoxonase 1 gene polymorphisms are associated with an increased risk of breast cancer in a population of Chinese women

Junrong Wu, Min Fang, Xiaoping Zhou, Bo Zhu _ and Zhi Yang

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Oncotarget. 2017; 8:25362-25371. https://doi.org/10.18632/oncotarget.15911

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Abstract

Junrong Wu1,*, Min Fang1,*, Xiaoping Zhou2, Bo Zhu1, Zhi Yang3

1Department of Clinical Laboratory, The Affiliated Tumor Hospital of Guangxi Medical University, Nanning, 530021, Guangxi, China

2Department of Clinical Laboratory, The First Affiliated Hospital of Guangxi University of Chinese Medicine, Nanning, 530022, Guangxi, China

3Department of Nuclear Medicine, The Affiliated Tumor Hospital of Guangxi Medical University, Nanning, 530021, Guangxi, China

*These authors have contributed equally to this work

Correspondence to:

Bo Zhu, email: [email protected]

Zhi Yang, email: [email protected]

Keywords: breast cancer, paraoxonase 1, gene polymorphisms, menopausal

Received: July 28, 2016 Accepted: February 15, 2017 Published: March 06, 2017

ABSTRACT

In this study, we explored associations between paraoxonase 1 (PON1) L55M and Q192R gene polymorphisms and the risk of breast cancer in 365 female breast cancer patients and 378 healthy controls from the Guangxi region of southern China. The LM heterozygous and MM homozygous genotypes, as well as M carrier status and M alleles, were associated with an increased risk of breast cancer. In addition, the M allele was associated with postmenopausal status and increased nodal involvement. In contrast, none of the Q192R genotypes or alleles were associated with a change in breast cancer risk, or with any of the clinicopathological parameters. These results indicate that PON1 L55M genetic polymorphisms may be associated with the risk of breast cancer and could potentially serve as useful genetic markers for tumor prognosis in some populations of Chinese women.

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PII: 15911

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Research Papers:

Paraoxonase 1 gene polymorphisms are associated with an increased risk of breast cancer in a population of Chinese women

Abstract