Isoform expression patterns of EPHA10 protein mediate breast cancer progression by regulating the E-Cadherin and β-catenin complex

Ye Li; Lu Jin; Fei Ye; Quanfu Ma; Zongyuan Yang; Dan Liu; Jie Yang; Ding Ma; Qinglei Gao

doi:10.18632/oncotarget.15910

Oncotarget

Oncotarget (a primarily oncology-focused, peer-reviewed, open access journal) aims to maximize research impact through insightful peer-review; eliminate borders between specialties by linking different fields of oncology, cancer research and biomedical sciences; and foster application of basic and clinical science.

Its scope is unique. The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. The term was introduced in the inaugural Editorial, Introducing Oncotarget.

As of January 1, 2022, Oncotarget has shifted to a continuous publishing model. Papers will now be published continuously within yearly volumes in their final and complete form and then quickly released to Pubmed.

Subscribe to receive alerts once a paper has been published by Oncotarget.

Impact Journals, LLC is the publisher of Oncotarget: www.impactjournals.com.

Impact Journals is a member of the Wellcome Trust List of Compliant Publishers.

Impact Journals is a member of the Society for Scholarly Publishing.

On December 23, 2022, Oncotarget server experienced a DDoS attack. As a result, Oncotarget site was inaccessible for a few hours. Oncotarget team swiftly dealt with the situation and took it under control. This malicious action will be reported to the FBI.

Research Papers:

Isoform expression patterns of EPHA10 protein mediate breast cancer progression by regulating the E-Cadherin and β-catenin complex

Ye Li, Lu Jin, Fei Ye, Quanfu Ma, Zongyuan Yang, Dan Liu, Jie Yang, Ding Ma and Qinglei Gao _

PDF | HTML | Supplementary Files | How to cite

Oncotarget. 2017; 8:30344-30356. https://doi.org/10.18632/oncotarget.15910

Metrics: PDF 1401 views | HTML 2732 views | ?

Abstract

Ye Li1,2, Lu Jin2, Fei Ye3, Quanfu Ma1, Zongyuan Yang1, Dan Liu1, Jie Yang1, Ding Ma1 and Qinglei Gao1

1Cancer Biology Research Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China

2Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University, Washington DC, USA

3Department of Neurosurgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China

Correspondence to:

Qinglei Gao, email: [email protected]

Keywords: EphA10s, EphA10, E-Cadherin complex, breast cancer, lymph node metastasis

Received: April 10, 2016 Accepted: February 07, 2017 Published: March 06, 2017

ABSTRACT

Overexpression of EPHA10 protein was reported in concomitance with clinical severity of breast cancer. In this study, we annotate overexpression of EPHA10 protein with changes of isoform expression as EphA10s (EPHA10 isoform 2) and EphA10 (EPHA10 isoform 3). In the process of malignant transformation, secretory protein EphA10s is in low expression, and pseudo-kinase EphA10 is overexpressed and cytoplasmically enriched. Down-regulated EphA10s blunts stabilization of membrane-associate β-catenin via the interaction with ephrin A5. Cytoplasmic EphA10 maintains phosphorylation of E-cadherin. Restoring isoform expression pattern by up-regulated EphA10s and down-regulated cytoplasmic EphA10 inhibits cell invasion and lymph node metastasis by strengthening the stability of the complex of E-cadherin and β-catenin in membrane. Taken together, we defined the novel interaction via expression patterns of EphA10s and EphA10 that promote malignant transformation of breast cancer, and demonstrated the potential benefit in clinical usage.

All site content, except where otherwise noted, is licensed under a Creative Commons Attribution 4.0 License.
PII: 15910

Publication Alerts

Research Papers:

Isoform expression patterns of EPHA10 protein mediate breast cancer progression by regulating the E-Cadherin and β-catenin complex

Abstract