Oncotarget

Clinical Research Papers:

Mean platelet volume, platelet distribution width and carcinoembryonic antigen to discriminate gastric cancer from gastric ulcer

Zhi-Yuan Yun, Na Li, Xin Zhang, Huan Zhang, Yue Bu, Yuxiang Sun, Tiemin Liu, Rui-Tao Wang and Kai-Jiang Yu _

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Oncotarget. 2017; 8:62600-62605. https://doi.org/10.18632/oncotarget.15898

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Abstract

Zhi-Yuan Yun1,*, Na Li1,*, Xin Zhang1, Huan Zhang1, Yue Bu2, Yuxiang Sun3, Tiemin Liu1,4, Rui-Tao Wang1 and Kai-Jiang Yu2

1 Department of Internal Medicine, Harbin Medical University Cancer Hospital, Harbin Medical University, Harbin, Heilongjiang, China

2 Department of Intensive Care Unit, Harbin Medical University Cancer Hospital, Harbin Medical University, Harbin, Heilongjiang, China

3 Departments of Pediatrics & Molecular and Cellular Biology, Children’s Nutrition Research Center, Huffington Center on Aging, Baylor College of Medicine, Houston, TX, USA

4 Department of Internal Medicine, Division of Hypothalamic Research, UT Southwestern Medical Center, Dallas, TX, USA

* These authors have contributed equally to this work

Correspondence to:

Rui-tao Wang, email:

Kai-jiang Yu, email:

Keywords: gastric cancer, mean platelet volume, platelet distribution width, diagnosis

Received: October 02, 2016 Accepted: February 21, 2017 Published: March 04, 2017

Abstract

Activated platelets are involved in cancer development and progression. Mean platelet volume (MPV) and platelet distribution width (PDW) are early indexes of platelet activation. The objectives of this study were to investigate the ability of MPV, PDW and carcinoembryonic antigen (CEA) individually or in combination, to distinguish between gastric cancer and gastric ulcer. The study involved 194 patients with gastric cancer, 191 patients with gastric ulcer, and 185 control subjects. Subjects’ characteristics and hematologic tests data at initial diagnosis were collected. We found that MPV levels are significantly increased and PDW levels are significantly reduced in patients with gastric ulcer and in control subjects compared with those in gastric cancer. When the area under the curve (AUC) was used to analyze control subjects versus gastric cancer, the combination of PDW and CEA exhibited a significantly larger AUC of 0.939 (0.910-0.961) compared with the combination of MPV and CEA (p = 0.0045). When AUC was used to analyze gastric ulcer versus gastric cancer, PDW alone had the high specificity (98.5%) and high sensitivity (97.4%). In conclusion, combined use of MPV, PDW and CEA can accurately distinguish gastric cancer from gastric ulcer and controls. Further studies in larger samples are warranted.


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