Heat shock proteins in multiple myeloma
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Lei Zhang1, Jacqueline H.L. Fok1 and Faith E. Davies1
1 Haemato-Oncology Research Unit, Division of Molecular Pathology, Cancer Therapeutics and Clinical Studies, The Institute of Cancer Research, London, UK
Faith E. Davies, email:
Keywords: heat shock proteins, multiple myeloma, protein folding, ER stress, haematology
Received: November 7, 2013 Accepted: January 17, 2014 Published: January 19, 2014
Heat shock proteins are molecular chaperones with a central role in protein folding and cellular protein homeostasis. They also play major roles in the development of cancer and in recent years have emerged as promising therapeutic targets. In this review, we discuss the known molecular mechanisms of various heat shock protein families and their involvement in cancer and in particular, multiple myeloma. In addition, we address the current progress and challenges in pharmacologically targeting these proteins as anti-cancer therapeutic strategies
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