Fine tuning of vitamin D receptor (VDR) activity by post-transcriptional and post-translational modifications

Ondrej Zenata; Radim Vrzal

doi:10.18632/oncotarget.15697

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Fine tuning of vitamin D receptor (VDR) activity by post-transcriptional and post-translational modifications

Ondrej Zenata and Radim Vrzal _

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Oncotarget. 2017; 8:35390-35402. https://doi.org/10.18632/oncotarget.15697

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Abstract

Ondrej Zenata1 and Radim Vrzal1

1 Department of Cell Biology and Genetics, Faculty of Science, Palacky University, Olomouc, Czech Republic

Correspondence to:

Radim Vrzal, email:

Ondrej Zenata, email:

Keywords: miRNA, phosphorylation, ubiquitination, sumoylation, VDRB1

Received: December 28, 2016 Accepted: February 08, 2017 Published: February 25, 2017

Abstract

Vitamin D receptor (VDR) is a member of the nuclear receptor (NR) superfamily of ligand-activated transcription factors. Activated VDR is responsible for maintaining calcium and phosphate homeostasis, and is required for proper cellular growth, cell differentiation and apoptosis. The expression of both phases I and II drug-metabolizing enzymes is also regulated by VDR, therefore it is clinically important.

Post-translational modifications of NRs have been known as an important mechanism modulating the activity of NRs and their ability to drive the expression of target genes. The aim of this mini review is to summarize the current knowledge about post-transcriptional and post-translational modifications of VDR.

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Fine tuning of vitamin D receptor (VDR) activity by post-transcriptional and post-translational modifications

Abstract