Oncotarget

Clinical Research Papers:

Lymph node status as a prognostic factor after palliative resection of primary tumor for patients with metastatic colorectal cancer

Qingguo Li, Changjian Wang, Yaqi Li, Xinxiang Li, Ye Xu, Guoxiang Cai, Peng Lian and Sanjun Cai _

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Oncotarget. 2017; 8:48333-48342. https://doi.org/10.18632/oncotarget.15696

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Abstract

Qingguo Li1,2,*, Changjian Wang3,*, Yaqi Li1,2,*, Xinxiang Li2,3, Ye Xu1,2, Guoxiang Cai1,2, Peng Lian1,2 and Sanjun Cai1,2

1 Department of Colorectal Surgery, Fudan University Shanghai Cancer Center, Shanghai, China

2 Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China

3 Anorectal Department, Hangzhou Third Hospital, Hangzhou, China

* These authors have contributed equally to this work

Correspondence to:

Sanjun Cai, email:

Peng Lian, email:

Keywords: metastatic colorectal cancer; palliative resection; lymph node status; survival analysis

Received: January 12, 2017 Accepted: February 20, 2017 Published: February 25, 2017

Abstract

Lymph node (LN) status is one of the most important predictors for M0 colorectal cancer patients. However, its clinical impact on stage IV colorectal cancer remains unclear. The study aimed to explore the prognostic value of LN status after palliative resection of primary tumor for patients with metastatic colorectal cancer (mCRC). We combined analyses of mCRC patients in Surveillance, Epidemiology and End Results (SEER) database and Fudan University Shanghai Cancer Center (FUSCC).A total of 17,553 patients with mCRC were identified in SEER database. X-tile program was adopted to identify 2 and 10 as optimal cutoff values for negative lymph node (NLN) count to divide patients into 3 subgroups of high, middle and low risk of cancer related death. N stage and NLN count were verified as independent prognostic factors in multivariate analyses of patients in whole cohort and in subgroup analyses of each N stage (P<0.05). Validation of FUSCC cohort of patients demonstrated that metastatic tumor burden (P = 0.042), NLN count (P = 0.039) and sequential chemotherapy (P = 0.040) were significant predictors of poorer CSS. Specifically, the prognosis of patients at stage N0 was significantly more favorable than that of patients at stage N2 (P = 0.038). In conclusion, primary tumor LN status was a strong predictor of CSS after palliative resection of metastatic colorectal cancer. Advanced N stage and small number of NLN were correlated with high risk of cancer related death after palliative resection of primary tumor.


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