Oncotarget

Clinical Research Papers:

Preoperative serum lipids as prognostic predictors in esophageal squamous cell carcinoma patients with esophagectomy

Pengxiang Chen, Lihui Han, Cong Wang, Yibin Jia, Qingxu Song, Jianbo Wang, Shanghui Guan, Bingxu Tan, Bowen Liu, Wenqiao Jia, Jianfeng Cui, Wei Zhou and Yufeng Cheng _

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Oncotarget. 2017; 8:41605-41619. https://doi.org/10.18632/oncotarget.15651

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Abstract

Pengxiang Chen1, Lihui Han1, Cong Wang1, Yibin Jia1, Qingxu Song1, Jianbo Wang1, Shanghui Guan1, Bingxu Tan1, Bowen Liu1, Wenqiao Jia1, Jianfeng Cui2, Wei Zhou1 and Yufeng Cheng1

1 Department of Radiation Oncology, Qilu Hospital of Shandong University, Jinan, People’s Republic of China

2 Department of Urology, Qilu Hospital of Shandong University, Jinan, People’s Republic of China

Correspondence to:

Yufeng Cheng, email:

Keywords: esophageal cancer, squamous cell carcinoma, serum lipids, prognosis

Received: August 06, 2016 Accepted: January 06, 2017 Published: February 23, 2017

Abstract

This study was to evaluate the prognostic significance of serum lipids in esophageal squamous cell carcinoma patients who underwent esophagectomy. Preoperative serum lipids were collected from 214 patients who were diagnosed with esophageal squamous cell carcinoma. All of the patients received esophagectomy in Qilu Hospital of Shandong University from January 2007 to December 2008. The records and data were analyzed retrospectively. We found that low total cholesterol (for T stage, p = 0.006; for TNM stage, p = 0.039) and low-density lipoprotein cholesterol (for T stage, p = 0.031; for TNM stage, p = 0.035) were associated with advanced T stage and TNM stage. Kaplan-Meier survival analysis indicated that low total cholesterol and low-density lipoprotein cholesterol were associated with shorter disease-free survival(for total cholesterol, p = 0.045; for low-density lipoprotein cholesterol, p < 0.001) and overall survival (for total cholesterol, p = 0.043; for low-density lipoprotein cholesterol, p < 0.001). Lower low-density lipoprotein cholesterol/high-density lipoprotein cholesterol ratio (LHR) indicated poorer disease-free survival and overall survival (both p < 0.001). In the multivariate analysis, low-density lipoprotein cholesterol and LHR were independent prognostic factors for disease-free survival and overall survival. In conclusion, our study indicated that preoperative serum total cholesterol and low-density lipoprotein cholesterol are prognostic factors for esophageal squamous cell carcinoma patients who underwent esophagectomy. LHR can serve as a promising serum lipids-based prognostic indicator.


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