Platelet distribution width correlates with prognosis of gastric cancer

Xin Zhang; Ming-ming Cui; Shuang Fu; Lu-lu Li; Yan-song Liu; Zhi-ping Liu; Tiemin Liu; Rui-tao Wang; Kai-jiang Yu

doi:10.18632/oncotarget.15561

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Research Papers:

Platelet distribution width correlates with prognosis of gastric cancer

Xin Zhang, Ming-ming Cui, Shuang Fu, Lu-lu Li, Yan-song Liu, Zhi-ping Liu, Tiemin Liu, Rui-tao Wang _ and Kai-jiang Yu

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Oncotarget. 2017; 8:20213-20219. https://doi.org/10.18632/oncotarget.15561

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Abstract

Xin Zhang1,*, Ming-Ming Cui1,*, Shuang Fu1, Lu-Lu Li2, Yan-Song Liu3, Zhi-Ping Liu4, Tiemin Liu5, Rui-Tao Wang1, Kai-Jiang Yu3

1Department of Internal Medicine, The Third Affiliated Hospital, Harbin Medical University, Harbin, Heilongjiang, 150081, China

2Department of Geriatrics, The Second Affiliated Hospital, Harbin Medical University, Harbin, Heilongjiang, 150086, China

3Department of Intensive Care Unit, The Third Affiliated Hospital, Harbin Medical University, Harbin, Heilongjiang, 150081, China

4Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA

5Division of Hypothalamic Research, Department of Internal Medicine, UT Southwestern Medical Center, Dallas, TX, 75390, USA

*These authors have contributed equally to this work

Correspondence to:

Rui-Tao Wang, email: [email protected]

Kai-Jiang Yu, email: [email protected]

Keywords: gastric cancer, platelet distribution width, prognosis, survival

Received: September 27, 2016 Accepted: January 17, 2017 Published: February 21, 2017

ABSTRACT

Background: Activated platelets promote tumor cell growth, aberrant angiogenesis, and invasion. However, the value of platelet indices for predicting survival in gastric cancer remains unknown. The goal of this study was to investigate the predictive significance of platelet indices in gastric cancer.

Result: Reduced platelet distribution width (PDW) was significantly correlated with age, carcinoembryonic antigen, tumor stage, nodule stage, and tumor-nodule-metastases stage. Moreover, decreased PDW correlated with a shorter overall survival in gastric cancer. Multivariate analysis identified PDW as an independent prognostic factor for overall survival (hazard ratio: 0.493, 95% confidence interval: 0.319-0.761, p = 0.001).

Method: A total of 294 patients with gastric cancer were retrospectively analyzed between January 2009 and December 2009. The association between platelet indices and overall survival were evaluated. The prognostic analysis was carried out with Cox regression model.

Conclusion: PDW is easily available with routine blood counts. Our data revealed that reduced PDW is unfavorable prognostic factor in gastric cancer. Further studies are warranted.

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Research Papers:

Platelet distribution width correlates with prognosis of gastric cancer

Abstract