Association of the long non-coding RNA MALAT1 with the polycomb repressive complex pathway in T and NK cell lymphoma

Soo Hee Kim; Se Hoon Kim; Woo Ick Yang; Soo Jeong Kim; Sun Och Yoon

doi:10.18632/oncotarget.15453

Oncotarget

Oncotarget (a primarily oncology-focused, peer-reviewed, open access journal) aims to maximize research impact through insightful peer-review; eliminate borders between specialties by linking different fields of oncology, cancer research and biomedical sciences; and foster application of basic and clinical science.

Its scope is unique. The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. The term was introduced in the inaugural Editorial, Introducing Oncotarget.

As of January 1, 2022, Oncotarget has shifted to a continuous publishing model. Papers will now be published continuously within yearly volumes in their final and complete form and then quickly released to Pubmed.

Subscribe to receive alerts once a paper has been published by Oncotarget.

Impact Journals, LLC is the publisher of Oncotarget: www.impactjournals.com.

Impact Journals is a member of the Wellcome Trust List of Compliant Publishers.

Impact Journals is a member of the Society for Scholarly Publishing.

On December 23, 2022, Oncotarget server experienced a DDoS attack. As a result, Oncotarget site was inaccessible for a few hours. Oncotarget team swiftly dealt with the situation and took it under control. This malicious action will be reported to the FBI.

Research Papers:

Association of the long non-coding RNA MALAT1 with the polycomb repressive complex pathway in T and NK cell lymphoma

Soo Hee Kim, Se Hoon Kim, Woo Ick Yang, Soo Jeong Kim and Sun Och Yoon _

PDF | HTML | Supplementary Files | How to cite

Oncotarget. 2017; 8:31305-31317. https://doi.org/10.18632/oncotarget.15453

Metrics: PDF 1794 views | HTML 2662 views | ?

Abstract

Soo Hee Kim1,2, Se Hoon Kim1, Woo Ick Yang1, Soo Jeong Kim3 and Sun Och Yoon1

1Department of Pathology, Yonsei University College of Medicine, Seoul, Korea

2Anatomic Pathology Reference Lab, Seegene Medical Foundation, Seoul, Korea

3Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea

Correspondence to:

Sun Och Yoon, email: [email protected], [email protected]

Keywords: T and NK cell lymphomas, long non-coding RNA, MALAT1, polycomb repressive complex

Received: June 13, 2016 Accepted: January 31, 2017 Published: February 17, 2017

ABSTRACT

Recently, various long non-coding RNAs (lncRNAs) have been reported to have significant therapeutic or prognostic value. However, the expression of lncRNAs has not been investigated in T and NK cell lymphoma. Thus, we evaluated the biological and prognostic role of lncRNAs related to the polycomb repressive complex (PRC) and PRC markers in tissue samples and cell lines of T and NK cell lymphoma. Among the tested lncRNAs, MALAT1 was most highly expressed in clinical samples and cell lines. High expression of MALAT1 as well as BMI1 was related to poor prognosis in patients with mature T cell lymphoma. In the tissue samples, BMI1 expression showed a positive correlation with EZH2, SUZ12, H3K27me3, and MALAT1. Multiple linear regression analysis showed that BMI1 expression was independently associated with H3K27me3. Direct binding of MALAT1 to the PRC2 components (EZH2 and SUZ12) was observed in a T cell lymphoma cell line; however, no direct binding of MALAT1 with H3K27me3 and BMI1 (a PRC1 component) was observed.

In T and NK cell lymphomas, MALAT1 was related to poor prognosis. MALAT1 directly binds to EZH2 and SUZ12, and BMI1 activation may be induced possibly through H3K27me3.

All site content, except where otherwise noted, is licensed under a Creative Commons Attribution 4.0 License.
PII: 15453

Publication Alerts

Research Papers:

Association of the long non-coding RNA MALAT1 with the polycomb repressive complex pathway in T and NK cell lymphoma

Abstract