Impact of DNA repair gene polymorphisms on the risk of biochemical recurrence after radiotherapy and overall survival in prostate cancer

Chiara Zanusso; Roberto Bortolus; Eva Dreussi; Jerry Polesel; Marcella Montico; Erika Cecchin; Sara Gagno; Flavio Rizzolio; Mauro Arcicasa; Giacomo Novara; Giuseppe Toffoli

doi:10.18632/oncotarget.15282

Oncotarget

Oncotarget (a primarily oncology-focused, peer-reviewed, open access journal) aims to maximize research impact through insightful peer-review; eliminate borders between specialties by linking different fields of oncology, cancer research and biomedical sciences; and foster application of basic and clinical science.

Its scope is unique. The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. The term was introduced in the inaugural Editorial, Introducing Oncotarget.

As of January 1, 2022, Oncotarget has shifted to a continuous publishing model. Papers will now be published continuously within yearly volumes in their final and complete form and then quickly released to Pubmed.

Subscribe to receive alerts once a paper has been published by Oncotarget.

Impact Journals, LLC is the publisher of Oncotarget: www.impactjournals.com.

Impact Journals is a member of the Wellcome Trust List of Compliant Publishers.

Impact Journals is a member of the Society for Scholarly Publishing.

On December 23, 2022, Oncotarget server experienced a DDoS attack. As a result, Oncotarget site was inaccessible for a few hours. Oncotarget team swiftly dealt with the situation and took it under control. This malicious action will be reported to the FBI.

Research Papers:

Impact of DNA repair gene polymorphisms on the risk of biochemical recurrence after radiotherapy and overall survival in prostate cancer

Chiara Zanusso, Roberto Bortolus, Eva Dreussi, Jerry Polesel, Marcella Montico, Erika Cecchin, Sara Gagno, Flavio Rizzolio, Mauro Arcicasa, Giacomo Novara and Giuseppe Toffoli _

PDF | HTML | Supplementary Files | How to cite

Oncotarget. 2017; 8:22863-22875. https://doi.org/10.18632/oncotarget.15282

Metrics: PDF 2148 views | HTML 2285 views | ?

Abstract

Chiara Zanusso1, Roberto Bortolus2, Eva Dreussi1, Jerry Polesel3, Marcella Montico1, Erika Cecchin1, Sara Gagno1, Flavio Rizzolio1, Mauro Arcicasa2, Giacomo Novara4, Giuseppe Toffoli1

1Experimental and Clinical Pharmacology Unit, National Cancer Institute, Aviano, PN, Italy

2Department of Radiation Oncology, National Cancer Institute, Aviano, PN, Italy

3Epidemiology and Biostatistics Unit, National Cancer Institute, Aviano, PN, Italy

4Department of Surgery, Oncology, and Gastroenterology, University of Padua, Padua, Italy

Correspondence to:

Giuseppe Toffoli, email: [email protected]

Keywords: prostate cancer, polymorphisms, biochemical recurrence, overall survival, DNA repair

Received: October 19, 2016 Accepted: January 27, 2017 Published: February 11, 2017

ABSTRACT

The identification of biomarkers of biochemical recurrence (BCR) in prostate cancer (PCa) patients undergoing radiotherapy (RT) represents an unanswered clinical issue. The primary aim of this study was the definition of new genetic prognostic biomarkers in DNA repair genes (DRGs), considering both BCR and overall survival (OS) as clinical end-points. The secondary aim was to explore the potential clinical impact of these genetic variants with the decision curve analysis (DCA) and the sensitivity analysis.

We analyzed 22 germline polymorphisms in 14 DRGs on 542 Caucasian PCa patients treated with RT as primary therapy. Significant associations were further tested with a bootstrapping technique. According to our analyses, ERCC2-rs1799793 and EXO1-rs4149963 were significantly associated with BCR (p = 0.01 and p = 0.01, respectively). Moreover, MSH6-rs3136228 was associated with a worse OS (p = 0.04). Nonetheless, the DCA and the sensitivity analyses gave no ultimate response about the clinical impact of such variants.

This study highlights the potential prognostic role of polymorphisms in DRGs for PCa, paving the way to the introduction of not invasive tools for the personalization of patients management. Nonetheless, other prospective studies are necessary to ultimately clarify the clinical impact of pharmacogenetics in PCa.

All site content, except where otherwise noted, is licensed under a Creative Commons Attribution 4.0 License.
PII: 15282

Publication Alerts

Research Papers:

Impact of DNA repair gene polymorphisms on the risk of biochemical recurrence after radiotherapy and overall survival in prostate cancer

Abstract