Oncotarget

Research Papers:

Time trends in the prevalence and epidemiological characteristics of neural tube defects in Liaoning Province, China, 2006-2015: A population-based study

Tie-Ning Zhang, Ting-Ting Gong, Yan-Ling Chen, Qi-Jun Wu _, Yuan Zhang, Cheng-Zhi Jiang, Jing Li, Li-Li Li, Chen Zhou and Yan-Hong Huang

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Oncotarget. 2017; 8:17092-17104. https://doi.org/10.18632/oncotarget.15060

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Abstract

Tie-Ning Zhang1, Ting-Ting Gong2, Yan-Ling Chen3, Qi-Jun Wu4, Yuan Zhang5, Cheng-Zhi Jiang6, Jing Li7, Li-Li Li8, Chen Zhou9, Yan-Hong Huang7

1Department of Pediatrics, Shengjing Hospital of China Medical University, Shenyang, China

2Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, Shenyang, China

3Liaoning Women and Children’s Health Hospital, Shenyang, China

4Department of Clinical Epidemiology, Shengjing Hospital of China Medical University, Shenyang, China

5Department of Emergency, Shengjing Hospital of China Medical University, Shenyang, China

6School of Environmental and Chemical Engineering, Shenyang Ligong University, Shenyang, China

7Department of Science and Education, Shenyang Women and Children Health Care Centre, Shenyang, China

8Department of Children's Health Prevention, Shenyang Women and Children Health Care Centre, Shenyang, China

9Department of Information Statistics, Shenyang Women and Children Health Care Centre, Shenyang, China

Correspondence to:

Qi-Jun Wu, email: wuqj@sj-hospital.org

Keywords: epidemiology, neural tube defects, perinatal, prevalence, time trend

Received: October 09, 2016    Accepted: January 10, 2017    Published: February 03, 2017

ABSTRACT

To evaluate the time trends in the prevalence of neural tube defects and all their subtypes as well as to identify the epidemiological characteristics of these malformations documented in the Liaoning Province of northeast China from 2006 to 2015. This was a population-based observational study using data from 3,248,954 live births as well as from 6217 cases of neural tube defects, 1,600 cases of anencephaly, 2,029 cases of spina bifida, 404 cases of encephalocele, and 3,008 cases of congenital hydrocephalus from 14 cities in Liaoning Province from 2006 to 2015. All analyses were conducted using SPSS software. During the observational period, the prevalence of neural tube defects, anencephaly, spina bifida, encephalocele, and congenital hydrocephalus was 19.1, 4.9, 6.2, 1.2, and 9.3 per 10,000 live births, respectively. Significantly decreasing trends were observed in the prevalence of all these malformations except for encephalocele. Notably, relatively higher prevalence rates were found in isolated compared with non-isolated malformations, with significant differences in selected characteristics (e.g., prognosis status, gestational age, and birth weight) between isolated and non-isolated cases of these malformations. The prevalence of neural tube defects showed a downward trend in Liaoning Province from 2006 to 2015. However, more attention should be focused on non-isolated cases in the future because of the severe clinical manifestations. Future prevention efforts should be strengthened to reduce the risk of these malformations, especially the non-isolated subtype, in areas with high prevalence.


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