Relationship between LINC00341 expression and cancer prognosis

Meijian Liao; Bing Li; Shikuan Zhang; Qing Liu; Weijie Liao; Weidong Xie; Yaou Zhang

doi:10.18632/oncotarget.14843

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Research Papers:

Relationship between LINC00341 expression and cancer prognosis

Meijian Liao, Bing Li, Shikuan Zhang, Qing Liu, Weijie Liao, Weidong Xie and Yaou Zhang _

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Oncotarget. 2017; 8:15283-15293. https://doi.org/10.18632/oncotarget.14843

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Abstract

Meijian Liao1,2,*, Bing Li1,2,*, Shikuan Zhang2, Qing Liu1,2, Weijie Liao1,2, Weidong Xie2,3, Yaou Zhang2,3

1School of Life Sciences, Tsinghua University, Beijing 100084, P.R. China

2Key Lab in Healthy Science and Technology, Division of Life Science, Graduate School at Shenzhen, Tsinghua University, Shenzhen 518055, P.R. China

3Open FIESTA Center, Tsinghua University, Shenzhen 518055, P.R. China

*These authors contributed equally to this work

Correspondence to:

Weidong Xie, email: [email protected]

Yaou Zhang, email: [email protected]

Keywords: LncRNA, LINC00341, metastasis, meta-analysis, prognostication

Received: November 15, 2016 Accepted: January 17, 2017 Published: January 27, 2017

ABSTRACT

LINC00341 is a novel long intergenic non-protein coding RNA with unknown functions. In our report, we investigated LINC00341 expression and its prognostic value in cancer patients. DNA over-methylation triggered low expression of LINC00341 and that was associated with poor prognosis in cancers. A meta-analysis further confirmed that high expression of LINC00341 was associated with a better prognosis in cancer patients. Both gene set enrichment analysis and meta-analysis showed that LINC00341 inhibited cancer metastasis. Finally, a large-scale multicentre analysis supported a prognostic value of LINC00341 in cancers.

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Research Papers:

Relationship between LINC00341 expression and cancer prognosis

Abstract