Oncotarget

Reviews:

Long non-coding RNAs: a rising biotarget in colorectal cancer

Jian Luo, Jian Qu, Dong-Kai Wu, Zhi-Li Lu, Yue-Sheng Sun and Qiang Qu _

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Oncotarget. 2017; 8:22187-22202. https://doi.org/10.18632/oncotarget.14728

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Abstract

Jian Luo1,*, Jian Qu2,*, Dong-Kai Wu3, Zhi-Li Lu4, Yue-Sheng Sun5 and Qiang Qu1

1 Department of Pharmacy, Xiangya Hospital, Central South University, Changsha, P. R. China

2 Department of Pharmacy, The Second Xiangya Hospital, Central South University, Institute of Clinical Pharmacy, Central South University, Changsha, P. R. China

3 Department of Cardiothoracic Surgery, Xiangya Hospital, Central South University, Changsha, P. R. China

4 Department of Pathology, The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, P. R. China

5 Department of General Surgery, The Third Clinical College of Wenzhou Medical University, Wenzhou People’s Hospital, Wenzhou, P. R. China

* These authors have contributed equally to this work

Correspondence to:

Qiang Qu, email:

Keywords: colorectal cancer, long non-coding RNAs, invasion, epithelial-mesenchymal transition

Received: November 01, 2016 Accepted: January 09, 2017 Published: January 18, 2017

Abstract

Colorectal cancer (CRC) is a common gastrointestinal cancer, with a high incidence and high mortality. Long non-coding RNAs (lncRNAs) are involved in the development, invasion and metastasis, early diagnosis, prognosis, the chemoresistance and radioresistance of CRC through interference with mRNA activity, directly combining with proteins to regulate their activity or alter their localization, influencing downstream gene expression by inhibiting RNA polymerase and regulating gene expression as competing endogenous RNAs. Recent progress in next generation sequencing and transcriptome analysis has revealed that tissue and cancer-type specific lncRNAs could be useful prognostic markers. Here, the CRC-associated lncRNAs from recent studies until October 2016 are reviewed and multiple studies that have confirmed CRC-associated lncRNAs are summarized. This review may be helpful in understanding the overall relationships between the lncRNAs involved in CRC.


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