Biodegradable and biocompatible high elastic chitosan scaffold is cell-friendly both  in vitro  and  in vivo

Yichuan Pang; An Qin; Xianfeng Lin; Lin Yang; Qiang Wang; Zhengke Wang; Zhi Shan; Shengyun Li; Jiying Wang; Shunwu Fan; Qiaoling Hu

doi:10.18632/oncotarget.14709

Oncotarget

Oncotarget (a primarily oncology-focused, peer-reviewed, open access journal) aims to maximize research impact through insightful peer-review; eliminate borders between specialties by linking different fields of oncology, cancer research and biomedical sciences; and foster application of basic and clinical science.

Its scope is unique. The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. The term was introduced in the inaugural Editorial, Introducing Oncotarget.

As of January 1, 2022, Oncotarget has shifted to a continuous publishing model. Papers will now be published continuously within yearly volumes in their final and complete form and then quickly released to Pubmed.

Subscribe to receive alerts once a paper has been published by Oncotarget.

Impact Journals, LLC is the publisher of Oncotarget: www.impactjournals.com.

Impact Journals is a member of the Wellcome Trust List of Compliant Publishers.

Impact Journals is a member of the Society for Scholarly Publishing.

On December 23, 2022, Oncotarget server experienced a DDoS attack. As a result, Oncotarget site was inaccessible for a few hours. Oncotarget team swiftly dealt with the situation and took it under control. This malicious action will be reported to the FBI.

Methodological Research Paper:

Biodegradable and biocompatible high elastic chitosan scaffold is cell-friendly both in vitro and in vivo

Yichuan Pang, An Qin, Xianfeng Lin, Lin Yang, Qiang Wang, Zhengke Wang, Zhi Shan, Shengyun Li, Jiying Wang, Shunwu Fan and Qiaoling Hu _

PDF | HTML | Supplementary Files | How to cite

Oncotarget. 2017; 8:35583-35591. https://doi.org/10.18632/oncotarget.14709

Metrics: PDF 1832 views | HTML 2789 views | ?

Abstract

Yichuan Pang1,*, An Qin2,*, Xianfeng Lin3, Lin Yang1, Qiang Wang3, Zhengke Wang1, Zhi Shan3, Shengyun Li3, Jiying Wang3, Shunwu Fan3 and Qiaoling Hu1

1 Department of Polymer Science and Engineering, MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Zhejiang University, Hangzhou, China

2 Department of Orthopedic Surgery, Shanghai Key Laboratory of Orthopedic Implants, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China

3 Department of Orthopaedics, Sir Shaw Run Run Hospital, School of Medicine, Zhejiang University, Hangzhou, China

* These authors have contributed equal to this work

Correspondence to:

Qiaoling Hu, email:

An Qin, email:

Shunwu Fan, email:

Keywords: chitosan, elastic scaffold, osteogenesis, tissue engineering

Received: April 24, 2016 Accepted: December 05, 2016 Published: January 17, 2017

Abstract

Biodegradable and biocompatible macromolecule chitosan has been favored for a variety of clinical applications. We reported herein the fabrication of a novel chitosan scaffold with high elasticity. This scaffold can be easily compressed and thus enable the insertion of such scaffold into surgical lesions during minimal invasive surgeries. In addition, this novel scaffold can restore its shape when released. We evidenced that this high elastic scaffold has better biocompatibility than traditional chitosan scaffold. Therefore, this new chitosan material might lead to the manufacture of a variety of novel biodegradable biomedical materials and devices.

All site content, except where otherwise noted, is licensed under a Creative Commons Attribution 4.0 License.
PII: 14709

Publication Alerts

Methodological Research Paper:

Biodegradable and biocompatible high elastic chitosan scaffold is cell-friendly both in vitro and in vivo

Abstract