Research Papers:

Increased incidence of ectopic pregnancy after in vitro fertilization in women with decreased ovarian reserve

Shengli Lin, Rui Yang, Hongbin Chi, Ying Lian, Jiejing Wang, Shuo Huang, Cuiling Lu, Ping Liu _ and Jie Qiao

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Oncotarget. 2017; 8:14570-14575. https://doi.org/10.18632/oncotarget.14679

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Shengli Lin1,*, Rui Yang1,*, Hongbin Chi1, Ying Lian1, Jiejing Wang1, Shuo Huang1, Cuiling Lu1, Ping Liu1, Jie Qiao1

1Reproductive Medical Center, Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, China

*These authors have contributed equally to this work

Correspondence to:

Ping Liu, email: bysylp@sina.com

Keywords: IVF, decreased ovarian reserve, ectopic pregnancy

Received: November 04, 2016     Accepted: January 09, 2017     Published: January 16, 2017


The incidence of ectopic pregnancy after assisted reproductive technology is increased approximately 2.5–5-fold compared with natural conceptions.

Strategies were used to decrease the incidence of ectopic pregnancy, but ectopic pregnancy still occurs. In the present study, women were selected with decreased ovarian reserve (defined as FSH > 10 IU/L) aged 20 to 38 years who underwent IVF-ET between 2009 and 2014. These 2,061 women were age-matched with an equal number of women with normal ovarian reserve (defined as FSH ≤ 10 IU/L). During cycles following fresh embryo transfer, 93 patients were diagnosed with ectopic pregnancy. The incidence of ectopic pregnancy in clinical pregnancies was significantly higher in the decreased ovarian reserve than in the normal ovarian reserve group (5.51% vs. 2.99%). After adjusting for confounding factors, the incidence of ectopic pregnancy was significantly associated with decreased ovarian reserve. Our results showed that decreased ovarian reserve is an independent risk factor for ectopic pregnancy after in vitro fertilization-embryo transfer.

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