Potential roles of microRNAs and ROS in colorectal cancer: diagnostic biomarkers and therapeutic targets

Jingmei Lin; Chia-Chen Chuang; Li Zuo

doi:10.18632/oncotarget.14461

Oncotarget

Oncotarget (a primarily oncology-focused, peer-reviewed, open access journal) aims to maximize research impact through insightful peer-review; eliminate borders between specialties by linking different fields of oncology, cancer research and biomedical sciences; and foster application of basic and clinical science.

Its scope is unique. The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. The term was introduced in the inaugural Editorial, Introducing Oncotarget.

As of January 1, 2022, Oncotarget has shifted to a continuous publishing model. Papers will now be published continuously within yearly volumes in their final and complete form and then quickly released to Pubmed.

Subscribe to receive alerts once a paper has been published by Oncotarget.

Impact Journals, LLC is the publisher of Oncotarget: www.impactjournals.com.

Impact Journals is a member of the Wellcome Trust List of Compliant Publishers.

Impact Journals is a member of the Society for Scholarly Publishing.

On December 23, 2022, Oncotarget server experienced a DDoS attack. As a result, Oncotarget site was inaccessible for a few hours. Oncotarget team swiftly dealt with the situation and took it under control. This malicious action will be reported to the FBI.

Reviews:

Potential roles of microRNAs and ROS in colorectal cancer: diagnostic biomarkers and therapeutic targets

Jingmei Lin, Chia-Chen Chuang and Li Zuo _

PDF | HTML | How to cite

Oncotarget. 2017; 8:17328-17346. https://doi.org/10.18632/oncotarget.14461

Metrics: PDF 3221 views | HTML 3626 views | ?

Abstract

Jingmei Lin1, Chia-Chen Chuang2,3 and Li Zuo2,3

1 Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN, USA

2 Radiologic Sciences and Respiratory Therapy Division, School of Health and Rehabilitation Sciences, The Ohio State University College of Medicine, Columbus, OH, USA

3 Interdisciplinary Biophysics Graduate Program, The Ohio State University, Columbus, OH, USA

Correspondence to:

Li Zuo, email:

Keywords: colorectal cancer, free radicals, microRNA, ROS, therapeutic targets

Received: May 04, 2016 Accepted: December 16, 2016 Published: January 03, 2017

Abstract

As one of the most commonly diagnosed cancers worldwide, colorectal adenocarcinoma often occurs sporadically in individuals aged 50 or above and there is an increase among younger patients under 50. Routine screenings are recommended for this age group to improve early detection. The multifactorial etiology of colorectal cancer consists of both genetic and epigenetic factors. Recently, studies have shown that the development and progression of colorectal cancer can be attributed to aberrant expression of microRNA. Reactive oxygen species (ROS) that play a key role in cancer cell survival, can also lead to carcinogenesis and cancer exacerbations. Given the rapid accumulating knowledge in the field, an updated review regarding microRNA and ROS in colorectal cancer is necessary. An extensive literature search has been conducted in PubMed/Medline databases to review the roles of microRNAs and ROS in colorectal cancer. Unique microRNA expression in tumor tissue, peripheral blood, and fecal samples from patients with colorectal cancer is outlined. Therapeutic approaches focusing on microRNA and ROS in colorectal cancer treatment is also delineated. This review aims to summarize the newest knowledge on the pathogenesis of colorectal cancer in the hopes of discovering novel diagnostic biomarkers and therapeutic techniques.

All site content, except where otherwise noted, is licensed under a Creative Commons Attribution 4.0 License.
PII: 14461

Publication Alerts

Reviews:

Potential roles of microRNAs and ROS in colorectal cancer: diagnostic biomarkers and therapeutic targets

Abstract