Oncotarget

Research Papers: Pathology:

Variants in the SMARCA4 gene was associated with coronary heart disease susceptibility in Chinese han population

Xuan Guo _, Xiaohong Wang, Yuan Wang, Chunyan Zhang, Xiaohui Quan, Yan Zhang, Shan Jia, Weidong Ma, Yajie Fan and Congxia Wang

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Oncotarget. 2017; 8:7350-7356. https://doi.org/10.18632/oncotarget.14387

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Abstract

Xuan Guo1,2,*, Xiaohong Wang2,*, Yuan Wang3, Chunyan Zhang1, Xiaohui Quan2, Yan Zhang1, Shan Jia1, Weidong Ma1, Yajie Fan1 and Congxia Wang1

1 Department of Cardiovascular Medicine, The Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi 710004, China

2 Department of Cardiovascular Medicine, The First Hospital of Xi’an, Xi’an, Shaanxi 710004, China

3 The Department of Orthopedics, People’s Hospital of Manzhouli City, Manzhouli, Inner Mongolia 021400, China

* Joint first authors

Correspondence to:

Congxia Wang, email:

Keywords: SMARCA4, coronary heart disease, gene polymorphisms, case-control study, Pathology Section

Received: August 04, 2016 Accepted: November 21, 2016 Published: December 30, 2016

Abstract

Background: Coronary heart disease (CHD) is the leading cause of death worldwide. Many single-nucleotide polymorphisms (SNPs) are found to be related to the risk of CHD in previous studies. This study investigated whether polymorphism of SMARCA4 gene is associated with CHD.

Materials and methods: Genotypes at five CHD-relevant SNPs were determined in 456 cases of incident CHD and 685 unaffected controls in Chinese Han population using χ2 test, genetic model analysis and haplotype analysis. We also analysis the differences in continuous variables among the subjects with three genotypes of related genes were assessed using the ANOVA.

Results: We identified two susceptibility SNPs in the SMARCA4 gene that were potentially associated with a decreased risk of CHD. We identified rs11879293 (OR, 0.74; 95% CI, 0.59-0.96; P = 0.012) and rs12232780 (OR, 0.70; 95% CI, 0.54-0.90; P = 0.005) were associated with a decreased risk of CHD risk under the log-additive model adjusted by gender and age. Meanwhile, we also found that significant differences in glucose concentrations with rs11879293 and rs1122608 different genotype. Serum LDL-C and HDL-C were seen among the 3 genotypes of rs12232780 exist differences.

Conclusion: This study provides an evidence for polymorphism of SMARCA4 gene associated with CHD development in Chinese Han population.


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