Oncotarget

Research Papers:

Association of C5L2 genetic polymorphisms with coronary artery disease in a Han population in Xinjiang, China

Ying-Ying Zheng, Xiang Xie, Yi-Tong Ma _, Zhen-Yan Fu, Xiang Ma, Yi-Ning Yang, Xiao-Mei Li, Shuo Pan, Dilare Adi, Bang-Dang Chen and Fen Liu

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Oncotarget. 2017; 8:8590-8596. https://doi.org/10.18632/oncotarget.14353

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Abstract

Ying-Ying Zheng1,2,*, Xiang Xie1,2,*, Yi-Tong Ma1,2, Zhen-Yan Fu1,2, Xiang Ma1,2, Yi-Ning Yang1,2, Xiao-Mei Li1,2, Shuo Pan1,2, Dilare Adi1,2, Bang-Dang Chen2, Fen Liu2

1Department of Cardiology, First Affiliated Hospital of Xinjiang Medical University, Urumqi, 830054 P.R., China

2Coronary Heart Disease Laboratory, Xinjiang Key Laboratory of Cardiovascular Disease Research, Urumqi, 830054, P.R., China

*These authors have contributed equally to this work

Correspondence to:

Yi-Tong Ma, email: [email protected]

Keywords: C5L2 gene, single nucleotide polymorphism, acylation-stimulating protein, coronary artery disease

Received: October 04, 2016     Accepted: November 30, 2016     Published: December 29, 2016

ABSTRACT

Background: C5aR-like receptor 2 (C5L2) has been identified as a receptor for the inflammatory factor Complement 5a (C5a) and acylation-stimulating protein (ASP). ASP binding to C5L2 leading to a net accumulation of TG stores and glucose transporter. The aim of the present study is to evaluate the association of the SNPs of C5L2 gene with coronary artery disease (CAD) in a Chinese population.

Methods: We examined the role of the tagging single nucleotide polymorphisms (SNPs) of C5L2 gene for CAD using a case-control design. We determined the prevalence of C5L2 genotypes in 505 CAD patients and 469 age and sex-matched healthy control subjects of Han population.

Results: There was significant difference in genotype distributions of rs2972607 and rs8112962 between CAD patients and control subjects. The rs2972607 was found to be associated with CAD in a dominant model (AA vs. AG + GG, P<0.001). Similarly, the rs8112962 was found to be associated with CAD in a dominant model (TT vs CT + CC, P=0.016). The difference remained statistically significant after multivariate adjustment (OR =1.401, 95% confidence interval [CI]:1.026~1.914, P=0.034; OR = 1.541, 95%CI:1.093~ 2.172, P=0.014; respectively).

Conclusion: The results of this study indicate that both rs2972607 and rs8112962 of C5L2 gene are associated with CAD in a Han population of China.


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