P4HB promotes HCC tumorigenesis through downregulation of GRP78 and subsequent upregulation of epithelial-to-mesenchymal transition

Wei Xia; Juhua Zhuang; Guoyu Wang; Jing Ni; Jiening Wang; Ying Ye

doi:10.18632/oncotarget.14337

Oncotarget

Oncotarget (a primarily oncology-focused, peer-reviewed, open access journal) aims to maximize research impact through insightful peer-review; eliminate borders between specialties by linking different fields of oncology, cancer research and biomedical sciences; and foster application of basic and clinical science.

Its scope is unique. The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. The term was introduced in the inaugural Editorial, Introducing Oncotarget.

As of January 1, 2022, Oncotarget has shifted to a continuous publishing model. Papers will now be published continuously within yearly volumes in their final and complete form and then quickly released to Pubmed.

Subscribe to receive alerts once a paper has been published by Oncotarget.

Impact Journals, LLC is the publisher of Oncotarget: www.impactjournals.com.

Impact Journals is a member of the Wellcome Trust List of Compliant Publishers.

Impact Journals is a member of the Society for Scholarly Publishing.

On December 23, 2022, Oncotarget server experienced a DDoS attack. As a result, Oncotarget site was inaccessible for a few hours. Oncotarget team swiftly dealt with the situation and took it under control. This malicious action will be reported to the FBI.

Research Papers:

P4HB promotes HCC tumorigenesis through downregulation of GRP78 and subsequent upregulation of epithelial-to-mesenchymal transition

Wei Xia, Juhua Zhuang, Guoyu Wang, Jing Ni, Jiening Wang and Ying Ye _

PDF | HTML | How to cite

Oncotarget. 2017; 8:8512-8521. https://doi.org/10.18632/oncotarget.14337

Metrics: PDF 2122 views | HTML 2917 views | ?

Abstract

Wei Xia1,*, Juhua Zhuang1,*, Guoyu Wang1, Jing Ni1, Jiening Wang2, Ying Ye1

1Department of Nuclear Medicine, Seventh People’s Hospital of Shanghai University of TCM, Shanghai, China

2Department of Integrated TCM & western medcine, President’s Office of Seventh People’s Hospital of Shanghai University of TCM, Shanghai, China

*These authors have contributed equally to this work and should be considered as co-first authors

Correspondence to:

Jiening Wang, email: [email protected]

Ying Ye, email: [email protected]

Keywords: P4HB, GRP78, hepatocellular carcinoma, tumorigenesis, epithelial-to-mesenchymal transition

Received: July 25, 2016 Accepted: December 01, 2016 Published: December 28, 2016

ABSTRACT

P4HB and GRP78 are molecular chaperones involved in cellular response to ER stress. They have been linked to cancer progression; however, their roles in hepatocellular carcinoma (HCC) are largely unclear. In this study, we found that P4HB is overexpressed in human HCC tissues and cell lines. Higher tumoral P4HB levels are correlated with more advanced disease and poorer survival. GRP78 expression is inversely correlated with P4HB in human HCC tissues, and downregulated by P4HB in HCC cell lines. P4HB overexpression promotes HCC cell growth, migration, invasion and epithelial-to-mesenchymal transition (EMT) in vitro. GRP78 overexpression not only inhibits HCC cell growth, migration, invasion and EMT, but also antagonizes the oncogenic effects of P4HB overexpression. Furthermore, P4HB silencing inhibits HCC tumorigenesis in vivo. Taken together, our results provided evidence that P4HB promotes HCC progression through downregulation of GRP78 and subsequent upregulation of EMT.

All site content, except where otherwise noted, is licensed under a Creative Commons Attribution 4.0 License.
PII: 14337

Publication Alerts

Research Papers:

P4HB promotes HCC tumorigenesis through downregulation of GRP78 and subsequent upregulation of epithelial-to-mesenchymal transition

Abstract