Oncotarget

Research Papers:

Chemoembolization of liver cancer with drug-loading microsphere 50-100μm

Jun-Hui Sun, Guan-Hui Zhou, Yue-Lin Zhang, Chun-Hui Nie, Tan-Yang Zhou, Jing Ai, Tong-Yin Zhu, Wei-Lin Wang _ and Shu-Sen Zheng

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Oncotarget. 2017; 8:5392-5399. https://doi.org/10.18632/oncotarget.14281

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Abstract

Jun-Hui Sun1, Guan-Hui Zhou1, Yue-Lin Zhang1, Chun-Hui Nie1, Tan-Yang Zhou1, Jing Ai2, Tong-Yin Zhu1, Wei-Lin Wang1, Shu-Sen Zheng1

1Division of Hepatobiliary and Pancreatic Interventional Center, First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310003, P.R. China

2Department of Ophthalmology, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310009, P.R. China

Correspondence to:

Shu-Sen Zheng, email: shusenzheng@zju.edu.cn

Keywords: chemoembolization, TACE, liver cancer, hepasphere microsphere, drug eluting microsphere

Received: August 08, 2016    Accepted: December 07, 2016    Published: December 27, 2016

ABSTRACT

Transcatheter arterial chemoembolization (TACE) is the mainstay of treatment for unresectable hepatocellular carcinoma (HCC). The efficacy of conventional TACE (cTACE) in liver metastases is not satisfactory, which might be due to the fact of embolic material used. Recently, as a new type of drug-loading microsphere, HepaSphere has been introduced in China. In this study, there were total 30 patients (18 males and 12 females) with liver cancer underwent embolization with Hepasphere microsphere. And a total of 44 TACE procedures were performed using 50-100μm HepaSphere. There were 16 patients diagnosed as HCC and 14 patients as liver metastases. The follow up period ranged from 3 to 15 months (median 10 months). Response rates were calculated on intention-to-treat basis. One month after TACE, total objective response was 63.3% and disease control rate was 86.7%. No severe complication (such as infection, liver abscess, abdominal bleeding, tumor rupture) was observed. In conclusion, chemoembolization with Hepasphere microsphere may be a safe and possibly effective palliative treatment for patients with liver cancer.


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