Metabolic enzymes: key modulators of functionality in cancer stem-like cells

Bo-Wen Dong; Guang-Ming Qin; Yan Luo; Jian-Shan Mao

doi:10.18632/oncotarget.14041

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Metabolic enzymes: key modulators of functionality in cancer stem-like cells

Bo-Wen Dong, Guang-Ming Qin, Yan Luo and Jian-Shan Mao _

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Oncotarget. 2017; 8:14251-14267. https://doi.org/10.18632/oncotarget.14041

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Abstract

Bo-Wen Dong1, Guang-Ming Qin2, Yan Luo3, Jian-Shan Mao1

1Department of Gastroenterology, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China

2Department of Clinical Laboratory Medicine, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China

3School of Basic Medical Sciences, Zhejiang University, Hangzhou, China

Correspondence to:

Jian-Shan Mao, email: [email protected]

Keywords: cancer stem-like cells, metabolism, enzymes, stemness, mechanism

Received: August 02, 2016 Accepted: November 07, 2016 Published: December 20, 2016

ABSTRACT

Cancer Stem-like Cells (CSCs) are a subpopulation of cancer cells with self-renewal capacity and are important for the initiation, progression and recurrence of cancer diseases. The metabolic profile of CSCs is consistent with their stem-like properties. Studies have indicated that enzymes, the main regulators of cellular metabolism, dictate functionalities of CSCs in both catalysis-dependent and catalysis-independent manners. This paper reviews diverse studies of metabolic enzymes, and describes the effects of these enzymes on metabolic adaptation, gene transcription and signal transduction, in CSCs.

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Metabolic enzymes: key modulators of functionality in cancer stem-like cells

Abstract